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Table 2 Results of logistic regression analysis for prediction of abnormal CSF biomarkers across all three centers

From: Prevalence of abnormal Alzheimer’s disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples

Model/predictors

OR

(95% CI)

p value

R 2

ΔR2

OR

(95% CI)

p value

R 2

ΔR2

Model variables

Abnormal CSF-Aβ42 (< 813 pg/ml)

Abnormal CSF-tau (> 375 pg/ml)

 Step 1: covariates

  Age (per 1-year increase)

1.09

1.03–1.15

0.003

0.080

0.080

1.18

1.09–1.28

< 0.001

0.187

0.187

  Positive APOE ε4 status

2.34

1.10–5.00

0.028

0.126

0.046

6.20

2371–16.2

< 0.001

0.329

0.142

 Step 2: center (ADC = reference)

   

0.001

0.271

0.145

   

0.562

0.339

0.010

  DELCODE

6.54

2.14–20.0

0.001

  

0.841

0.241–2.94

0.786

  

  IDIBAPS

5.78

2.14–15.6

0.001

  

1.53

0.476–4.89

0.477

  

Model variables

Abnormal CSF-ptau181 (> 53 pg/ml)

Abnormal Aβ42 and abnormal ptau181

 Step 1: covariates

  Age (per 1-year increase)

Not selected

1.15

1.05–1.26

0.002

0.117

0.117

  Positive APOE ε4 status

2.66

1.28–5.54

0.009

0.069

0.069

5.23

1.80–15.2

0.002

0.234

0.117

 Step 2: center (ADC = reference)

   

0.728

0.075

0.006

   

0.393

0.255

0.021

  DELCODE

0.983

0.401–2.41

0.970

  

1.68

0.374–7.54

0.499

  

  IDIBAPS

1352

0.574–3.19

0.490

  

2.60

0.643–10.5

0.180

  
  1. R2 and ΔR2 give an estimate of explained variance of the full model and each predictor’s contribution of explained variance within the model, respectively
  2. No values are reported for nonsignificant predictor variables in step 1 of the models, as we used a forward selection process at this step
  3. amyloid beta, ADC Amsterdam Dementia Cohort, APOE apolipoprotein E, CI confidence interval, CSF cerebrospinal fluid, DELCODE German Center for Neurodegenerative Diseases (DZNE), IDIBAPS l’Institut d’Investigacions Biomèdiques August Pi i Sunyer Hospital Clinic Barcelona, OR odds ratio, ptau181 tau phosphorylated at position 181