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Table 1 Sociodemographic and clinical characteristics of ALFA participants

From: Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort

Sociodemographic and clinical variables (n = 561) Mean / n  Interquartile range / % 
CAIDE-I risk (%) 1.47 0.67–3.22
CAIDE-I score (0–15) 6 4–8
Age (years) 58 51–64
Hypertension, n (%) 147 26.2
Hypercholesterolemia, n (%) 171 30.5
BMI (kg/m2) 26.4 24.0–29.4
Sex (male), n (%) 219 38.9
Education (years) 14 11–17
Physical exercise, n (%)
 Active 368 65.6
 Not active 148 26.4
 Not available 45 8.0
APOE genotype, n (%)
ε4/ε4 71 12.7
ε4/ε3 170 30.3
ε3/ε3 159 28.3
ε2/ε4 45 8.0
ε2/ε3 109 19.4
ε2/ε2 7 1.2
Family history of AD, n (%)
 Maternal 190 33.9
 Paternal 91 16.2
 From both 16 2.9
 None 245 43.7
 Not available 19 3.4
Fazekas Scale, n (%)
 Score 0 269 48.0
 Score 1 247 44.0
 Score 2 43 7.7
 Score 3 2 0.4
Total WMH load (cm3) 1.94 1.13–3.69
Total WMH load/TIV (%) 0.14 0.08–0.26
MMSE 29 28–30
Time difference between visit and MRI (days) 307 251–366
  1. Values are expressed as median (interquartile range) unless otherwise indicated
  2. AD Alzheimer’s disease, APOE apolipoprotein E, BMI body mass index, CAIDE Cardiovascular Risk Factors, Aging, and Incidence of Dementia, MMSE Mini-Mental State Examination, MRI magnetic resonance imaging, TIV total intracranial volume, WMH white matter hyperintensities
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