|
Sociodemographic and clinical variables (n = 561)
|
Mean / n
|
Interquartile range / %
|
|---|
|
CAIDE-I risk (%)
|
1.47
|
0.67–3.22
|
|
CAIDE-I score (0–15)
|
6
|
4–8
|
|
Age (years)
|
58
|
51–64
|
|
Hypertension, n (%)
|
147
|
26.2
|
|
Hypercholesterolemia, n (%)
|
171
|
30.5
|
|
BMI (kg/m2)
|
26.4
|
24.0–29.4
|
|
Sex (male), n (%)
|
219
|
38.9
|
|
Education (years)
|
14
|
11–17
|
|
Physical exercise, n (%)
|
|
Active
|
368
|
65.6
|
|
Not active
|
148
|
26.4
|
|
Not available
|
45
|
8.0
|
|
APOE genotype, n (%)
|
|
ε4/ε4
|
71
|
12.7
|
|
ε4/ε3
|
170
|
30.3
|
|
ε3/ε3
|
159
|
28.3
|
|
ε2/ε4
|
45
|
8.0
|
|
ε2/ε3
|
109
|
19.4
|
|
ε2/ε2
|
7
|
1.2
|
|
Family history of AD, n (%)
|
|
Maternal
|
190
|
33.9
|
|
Paternal
|
91
|
16.2
|
|
From both
|
16
|
2.9
|
|
None
|
245
|
43.7
|
|
Not available
|
19
|
3.4
|
|
Fazekas Scale, n (%)
|
|
Score 0
|
269
|
48.0
|
|
Score 1
|
247
|
44.0
|
|
Score 2
|
43
|
7.7
|
|
Score 3
|
2
|
0.4
|
|
Total WMH load (cm3)
|
1.94
|
1.13–3.69
|
|
Total WMH load/TIV (%)
|
0.14
|
0.08–0.26
|
|
MMSE
|
29
|
28–30
|
|
Time difference between visit and MRI (days)
|
307
|
251–366
|
- Values are expressed as median (interquartile range) unless otherwise indicated
- AD Alzheimer’s disease, APOE apolipoprotein E, BMI body mass index, CAIDE Cardiovascular Risk Factors, Aging, and Incidence of Dementia, MMSE Mini-Mental State Examination, MRI magnetic resonance imaging, TIV total intracranial volume, WMH white matter hyperintensities
