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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort

Fig. 3

Regional patterns of WMH correlation with APOE and family history of AD. These models show correlations without any covariate (Model 1), correcting for age (Model 2), and correcting for hypertension (Model 3). Effect sizes of the correlation are shown only on regions that presented significant association (p < 0.05 FDR-corrected). Hot colors represent positive correlations between WMH and each particular condition, and cold colors negative associations. APOE-ε3ε3 carriers and participants without family history of AD were set as reference group. *Model of reference due to demographic characteristics of this group. AD Alzheimer’s disease, APOE apolipoprotein E, BG basal ganglia, FL left frontal lobe, FR right frontal lobe, PL left parietal lobe, PR right parietal lobe, OL left occipital lobe, OR right occipital lobe, TL left temporal lobe, TR right temporal lobe

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