Fig. 2

Regional patterns of WMH associations with CAIDE-I and each of the individual risk factors included in the scale. The individual risks of CAIDE-I are: age, hypertension, hypercholesterolemia, body mass index, sex, education, and physical exercise. Model 1 shows direct correlations without covariates (first column). Model 2 and Model 3 show correlations against WMH correcting by age and hypertension, respectively (second and third column). Effect sizes of the correlation are colored only on regions that showed significant association (p < 0.05 FDR-corrected). Hot colors represent positive correlations between WMH and each particular condition, and cold colors negative associations. In dichotomic comparisons, hypertensive, hypercholesterolemic, men, and active participants were set as reference groups. *Model of reference due to demographic characteristics of this group. BG basal ganglia, CAIDE-I Cardiovascular Risk Factors, Aging, and Incidence of Dementia percentage risk of dementia (model without APOE), FL left frontal lobe, FR right frontal lobe, PL left parietal lobe, PR right parietal lobe, OL left occipital lobe, OR right occipital lobe, TL left temporal lobe, TR right temporal lobe