From: Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study
Neuropathological outcomes | Predictors | AUC [95%CI] | Description of predictors by neuropathological outcome categories | |
---|---|---|---|---|
Absent | Present | |||
β-Amyloid load | Overall modela | 0.66 [0.56 - 0.77] | N=37 (23%) | N=126 (77%) |
APOE genotypeb | 0.63 [0.56 - 0.71] | |||
APOEε2 carriersc | 0.57 [0.50 - 0.64] | 10 (27%) | 16 (13%) | |
APOEε4 carriersc | 0.60 [0.55 - 0.65] | 2 (5%) | 31 (25%) | |
All genotypes (23/24/33/34/44)c,d | 0.62 [0.54 - 0.70] | 9/1/26/1/0 (24/3/70/3/0%) | 13/3/78/28/0 (11/2/64/23/0%) | |
Functioningb | 0.61 [0.51 - 0.70] | |||
Competence in Daily Activitiesc | 0.61 [0.51 - 0.70] | 2.7 (1.4) | 3.2 (1.4) | |
Tangle count | Overall modela | 0.64 [0.55 - 0.73] | N=64 (39%) | N=99 (61%) |
APOE genotypeb | 0.60 [0.54 - 0.67] | |||
APOEε4 carriersc | 0.61 [0.55 - 0.67] | 5 (8%) | 28 (29%) | |
APOE ε3ε3 genotypec | 0.59 [0.52 - 0.66] | 48 (75%) | 56 (58%) | |
All genotypes (23/24/33/34/44)c,d | 0.55 [0.48 - 0.62] | 10/1/48/4/0 (16/2/76/6/0%) | 12/3/56/25/0 (13/3/58/26/0%) | |
Cholesterolb | 0.60 [0.51 - 0.70] | |||
Totalc | 0.61 [0.51 - 0.70] | 5.6 (1.4) | 5.9 (1.2) | |
LDLc | 0.60 [0.50 - 0.69] | 3.6 (1.1) | 3.9 (1.0) | |
Functioningb | 0.59 [0.50 - 0.67] | |||
Subjective memory declinec | 0.59 [0.50 - 0.67] | 1.7 (0.6) | 1.9 (0.7) | |
Neuropathological AD | Overall modela | 0.68 [0.61 - 0.76] | N=86 (53%) | N=77 (47%) |
APOE genotypeb | 0.65 [0.59 - 0.71] | |||
APOEε2 carriersc | 0.57 [0.51 - 0.62] | 19 (23%) | 7 (9%) | |
APOEε4 carriersc | 0.62 [0.57 - 0.67] | 8 (10%) | 25 (33%) | |
All genotypes (23/24/33/34/44)c,d | 0.64 [0.58 - 0.70] | 17/2/59/6/0 (20/2/70/7/0%) | 5/2/45/23/0 (7/3/60/31/0%) | |
Sociodemographicsb | 0.62 [0.53 - 0.70] | |||
Social classc | 0.62 [0.53 - 0.70] | 6.4 (1.5) | 5.9 (1.2) | |
Functioningb | 0.58 [0.50 - 0.66] | |||
Subjective memory declinec | 0.58 [0.50 - 0.66] | 1.7 (0.6) | 1.9 (0.7) | |
Cerebral amyloid angiopathy | Overall modela | 0.66 [0.58 - 0.74] | N=56 (35%) | N=103 (65%) |
APOE genotypeb | 0.62 [0.55 - 0.69] | |||
APOEε4 carriersc | 0.63 [0.58 - 0.68] | 2 (4%) | 30 (30%) | |
APOE ε3ε3 genotypec | 0.59 [0.52 - 0.67] | 43 (78%) | 59 (59%) | |
All genotypes (23/24/33/34/44)c,d | 0.61 [0.55 - 0.68] | 10/1/43/1/0 (18/2/78/2/0%) | 11/3/59/27/0 (11/3/59/27/0%) | |
Comorbidityb | 0.59 [0.52 - 0.65] | |||
Cardiovascularc | 0.59 [0.52 - 0.65] | 48 (86%) | 70 (68%) | |
Sociodemographics | 0.58 [0.53 - 0.64] | |||
Gender, menc | 0.58 [0.53 - 0.64] | 5 (9%) | 26 (25%) | |
Cerebral macroinfarcts | Overall modela | 0.72 [0.64 - 0.79] | N=83 (51%) | N=80 (49%) |
Comorbidityb | 0.64 [0.58 - 0.70] | |||
Cerebrovascularc | 0.64 [0.58 - 0.70] | 4 (5%) | 26 (33%) | |
Cognitionb | 0.63 [0.54 - 0.72] | |||
MMSE Wordlistc | 0.63 [0.55 - 0.71] | 4.6 (1.3) | 4.0 (1.3) | |
MMSE Totalc | 0.62 [0.52 - 0.71] | 23.8 (4.6) | 22.0 (4.5) | |
Lifestyleb | 0.62 [0.53 - 0.70] | |||
BMIc | 0.62 [0.53 - 0.70] | 23.9 (4.1) | 25.5 (4.2) | |
Functioningb | 0.59 [0.51 - 0.66] | |||
Competence in Daily Activitiesc | 0.59 [0.51 - 0.66] | 2.9 (1.4) | 3.3 (1.3) | |
Cortical macroinfarcts | Overall modela | 0.71 [0.63 - 0.79] | N=116 (71%) | N=47 (29%) |
Comorbidityb | 0.64 [0.57 - 0.71] | |||
Cerebrovascularc | 0.64 [0.57 - 0.71] | 12 (10%) | 18 (38%) | |
APOE genotypeb | 0.60 [0.51 - 0.69] | |||
APOEε4 carriersc | 0.58 [0.51 - 0.65] | 18 (16%) | 15 (33%) | |
APOE ε3ε3 genotypec | 0.59 [0.50 - 0.68] | 80 (71%) | 24 (52%) | |
White matter macroinfarcts | Overall modela | 0.76 [0.65 - 0.87] | N=140 (86%) | N=23 (14%) |
Cholesterolb | 0.72 [0.60 - 0.83] | |||
HDLc | 0.68 [0.58 - 0.79] | 1.0 (0.3) | 0.9 (0.3) | |
LDLc | 0.70 [0.58 - 0.83] | 3.9 (1.0) | 3.2 (1.0) | |
Comorbidityb | 0.62 [0.51 - 0.73] | |||
Cerebrovascularc | 0.62 [0.51 - 0.73] | 21 (15%) | 9 (39%) | |
APOE genotypeb | 0.61 [0.50 - 0.71] | |||
APOEε2 carriersc | 0.61 [0.50 - 0.71] | 18 (13%) | 8 (35%) | |
Cerebral microinfarcts | Overall modela | 0.61 [0.51 - 0.71] | N=130 (83%) | N=26 (17%) |
Education yearsc | 0.61 [0.51 - 0.71] | 4.5 (2.9) | 3.3 (1.8) | |
Hippocampal Sclerosis | Overall modela | 0.78 [0.64 - 0.91] | N=151 (93%) | N=11 (7%) |
Cognitionb | 0.75 [0.59 - 0.92] | |||
MMSE Wordlistc | 0.68 [0.54 - 0.83] | 4.4 (1.3) | 3.6 (0.9) | |
MMSE Other tasksc | 0.74 [0.57 - 0.90] | 6.9 (1.5) | 5.8 (1.4) | |
MMSE Totalc | 0.72 [0.55 - 0.90] | 23.1 (4.6) | 22.3 (4.1) | |
Lifestyleb | 0.57 [0.42 - 0.71] | |||
Current smokingc | 0.57 [0.42 - 0.71] | 4 (3%) | 2 (18%) | |
TDP-43 | Overall modela | 0.69 [0.56 - 0.81] | N=139 (86%) | N=21 (13%) |
Zung depression scalec | 0.69 [0.56 - 0.81] | 27.5 (5.8) | 23.7 (2.8) |