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Table 3 Brain regions showing statistically significant gray matter volumetric decrease in pairwise comparisons between non-SCD, SCD+, and SCD– groups

From: Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort

Contrast

 

Label

MNI coordinates

Cluster

Peak

pFWE-corr

x

y

z

size

Z score

Peak

Cluster

SCD– > SCD+

Cluster 1

Left temporal middle

−59

−33

−12

345

4.13

0.117

0.459

Left temporal inferior

       

Cluster 2

Left temporal inferior

−33

−15

−44

801

4.05

0.151

0.164

Left fusiform

       

Cluster 3

Left temporal pole superior

−38

−11

−17

753

3.81

0.315

0.182

Left temporal middle

       

Left temporal superior

       

Left temporal pole middle

       

Cluster 4

Right cerebellum

30

−74

−20

734

3.73

0.393

0.190

Right Fusiform

       

Cluster 5

Left postcentral

−53

−20

30

208

3.72

0.401

0.625

Left supramarginal

       

Cluster 7

Right cerebellum

12

−66

−47

556

3.72

0.403

0.283

Vermis

       

Cluster 8

Vermis

−2

−59

−18

1540

3.68

0.437

0.037

Left cerebellum

       

Left fusiform

       

Right cerebellum

       

Cluster 9

Left cerebellum

−14

−68

−45

559

3.63

0.494

0.281

Cluster 10

Left occipital superior

−17

−77

29

340

3.59

0.536

0.464

Left precuneus

       

Left cuneus

       

Cluster 11

Right temporal inferior

47

−9

−38

420

3.59

0.541

0.386

Right temporal pole

       

Right fusiform

       

Cluster 12

Left temporal superior

−54

−45

15

428

3.54

0.593

0.379

Left temporal middle

       

SCD– > non-SCD

Cluster 1

Left temporal pole superior

−45

6

−17

4502

4.66

0.015

0.000

Left fusiform

       

Left temporal pole middle

       

Left temporal superior

       

Left hippocampus

       

Left parahippocampal

       

Left insula

       

Left amygdala

       

Cluster 2

Left cuneus

−17

−63

33

2216

4.56

0.022

0.011

Left occipital superior

       

Left precuneus

       

Right cuneus

       

Left calcarine

       

Cluster 3

Right fusiform

30

−77

−17

956

4.31

0.061

0.118

Right cerebellum

       

Right lingual

       

Right occipital inferior

       

Cluster 4

Left lingual

2

−57

−18

3020

4.28

0.068

0.003

Vermis

       

Left cerebellum

       

Left fusiform

       

Cluster 5

Right temporal pole middle

39

9

−33

1723

4.15

0.109

0.026

Right temporal inferior

       

Right temporal pole superior

       

Cluster 6

Right frontal inferior

50

2

20

1157

4.11

0.126

0.078

Right rolandic

       

Right precentral

       

Cluster 7

Left temporal middle

−59

−33

−12

317

3.99

0.183

0.489

Left temporal inferior

       

Cluster 8

Left occipital middle

−32

−75

15

123

3.93

0.220

0.749

Cluster 9

Right supramarginal

45

−30

33

189

3.72

0.404

0.651

Right postcentral

       

Cluster 10

Left temporal superior

−59

−35

12

250

3.58

0.551

0.569

Left temporal middle

       

Cluster 11

Left postcentral

−53

−17

32

396

3.58

0.554

0.408

Left parietal inferior

       

Left supramarginal

       

Cluster 12

Right cerebellum

−3

−68

−45

489

3.56

0.601

0.330

Left cerebellum

       

Cluster 13

Left rolandic

−60

−3

12

229

3.53

0.624

0.596

Left postcentral

       

Cluster 14

Right occipital superior

26

−71

33

109

3.40

0.617

0.771

  1. non-SCD not self-reporting cognitive decline, SCD– SCD with ≤ 3 SCDplus features, SCD+ SCD with > 3 SCDplus features, SCDplus subjective cognitive decline plus, MNI Montreal Neurological Institute, pFWE Family-wise Error-adjusted p-value