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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: A two-step immunoassay for the simultaneous assessment of Aβ38, Aβ40 and Aβ42 in human blood plasma supports the Aβ42/Aβ40 ratio as a promising biomarker candidate of Alzheimer’s disease

Fig. 5

Effect of APOE ε4 on Aβ measures in IP eluates and on frequency of dichotomized diagnostic classifications. No statistically significant effects of number of APOE ε4 alleles on plasma levels of a Aβ42, b Aβ40 and c Aβ38. In contrast, APOE genotype had a statistically significant effect on d Aβ42/Aβ40 (F test p < 0.001) and e Aβ42/Aβ38 (F test p < 0.001) ratios. f Proportion of AD-D patients seemed to increase with increasing number of APOE ε4 alleles. However, in the small sample size studied, this effect did not reach statistical significance (Fisher p value = 0.1). Statistical test were done after log transformation. Accordingly, scaling of y axes is logarithmic in (a)–(e). Aβ amyloid beta, AD-D dementia of the Alzheimer type, APOE apolipoprotein E, OD dementia due to other reasons

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