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Table 2 Recovery of amyloid-β 1–42, Tau, and pTau181 from 0.1-ml and 0.5-ml aliquots

From: Preanalytical approaches to improve recovery of amyloid-β peptides from CSF as measured by immunological or mass spectrometry-based assays

 

1–42

Tau

pTau181

YNC

AD

YNC

AD

YNC

AD

No. of subjects

20

81

20

81

20

81

Mean concentration 0.1 ml (pg/ml)

344

204

55.1

174

30.5

78.2

Mean concentration 0.5 ml (pg/ml)

499

299

58.0

164

29.2

76.8

p Value (mean concentration 0.1 ml vs. 0.5 ml)

< 0.0001

< 0.0001

ns

< 0.0001

ns

0.021

Mean change from 0.1 ml to 0.5 ml (%)

50.5

52.4

7.59

− 4.77

− 2.42

− 1.74

  1. Abbreviations: Aβ Amyloid-β, AD Alzheimer’s disease, ns Not significant, YNC Young normal control subject
  2. p Values calculated by paired t test