The impact of education on cortical thickness in amyloid-negative subcortical vascular dementia: cognitive reserve hypothesis

Table 3 Multivariate analysis for the correlation of education with cortical thickness

	Cth_Global		Cth_Frontal		Cth_Temporal		Cth_Parietal		Cth_Occipital
	B	p Value	B	p Value	B	p Value	B	p Value	B	p Value
PiB(−) svMCI
Model 1	−0.004	0.352	−0.005	0.278	−0.005	0.283	−0.004	0.310	−0.001	0.800
Model 2	−0.004	0.375	−0.004	0.438	−0.004	0.398	−0.007	0.146	−0.001	0.880
Model 3	−0.001	0.823	0.001	0.859	−0.002	0.717	−0.004	0.359	0.001	0.758
PiB(−) SVaD
Model 1	−0.016	0.028*	−0.020	0.019*	−0.014	0.115	−0.017	0.014*	−0.013	0.047*
Model 2	−0.020	0.024*	−0.023	0.024*	−0.019	0.078	−0.021	0.012*	−0.016	0.035*
Model 3	−0.020	0.029*	−0.023	0.032*	−0.020	0.065	−0.021	0.017*	−0.016	0.046*

Abbreviations: Cth cortical thickness, PiB Pittsburgh Compound B, svMCI Subcortical vascular mild cognitive impairment, SVaD Subcortical vascular dementia
* p < 0.05
Multiple linear regression was performed after controlling for the covariates as follows:
Model 1: age, sex, ICV, and MMSE control
Model 2: age, sex, ICV, MMSE, hypertension, diabetes, hyperlipidemia, and smoking control
Model 3: age, sex, ICV, MMSE, hypertension, diabetes, hyperlipidemia, smoking, sqrtWMH, and sqrtLacune control

ISSN: 1758-9193