Table 1 Baseline characteristics by diagnosis and amyloid status
From: MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study
Characteristic | Cognitively normal | Mild cognitive impairment | Alzheimer-type dementia | |||
|---|---|---|---|---|---|---|
Amyloid negative | Amyloid positive | Amyloid negative | Amyloid positive | Amyloid negative | Amyloid positive | |
N, % within diagnosis | 245 (73) | 92 (27) | 140 (37) | 235 (63) | 3 (3) | 95 (97) |
Age (years) | 66.1 ± 7.2 | 67.5 ± 7.2 | 67.3 ± 8.0 | 70.2 ± 7.0*** | 63.1 ± 8.0 | 67.1 ± 7.7 |
Male gender | 120 (49) | 47 (51) | 73 (52) | 105 (45) | 3 (100) | 48 (51) |
Education (years) | 13.2 ± 3.5 | 12.8 ± 3.8 | 10.8 ± 4.0 | 11.1 ± 3.7 | 10.3 ± 5.1 | 11.1 ± 3.3 |
MMSE | 28.9 ± 1.2 | 28.8 ± 1.2 | 27.1 ± 2.2 | 26.0 ± 2.6*** | 27.7 ± 1.2 | 22.4 ± 4.0** |
Memory immediate | 0.10 ± 1.00 | 0.08 ± 1.10 | − 0.64 ± 1.32 | −1.22 ± 1.44*** | −0.45 ± 0.91 | −2.25 ± 1.06 |
Memory delayed | 0.25 ± 1.01 | 0.30 ± 1.09 | −0.90 ± 1.29 | − 1.37 ± 1.41** | −0.96 ± 1.33 | − 2.28 ± 1.04 |
Language | −0.21 ± 1.01 | 0.01 ± 1.04 | −0.65 ± 1.30 | −0.88 ± 1.27 | −0.76 ± 0.38 | −1.95 ± 1.02* |
Attention | 0.32 ± 1.03 | 0.26 ± 0.89 | −0.74 ± 1.79 | −0.81 ± 1.63 | 0.54 ± 0.52 | − 2.03 ± 1.94* |
Executive functioning | 0.35 ± 1.09 | 0.12 ± 1.15 | − 0.76 ± 1.89 | −1.11 ± 1.98* | 0.46 ± 0.32 | −2.49 ± 2.46* |
Visuo-construction | − 0.23 ± 1.36 | − 0.19 ± 1.20 | 0.18 ± 1.46 | −0.30 ± 1.66* | −0.59 ± 2.09 | −1.30 ± 2.00 |
APOE ε4 genotype | 89 (36) | 53 (58)*** | 27 (19) | 160 (66)*** | 2 (67) | 66 (69) |
Available markers | ||||||
Visual | 245 (100) | 92 (100) | 140 (100) | 235 (100) | 3 (100) | 95 (100) |
Subcortical volumes | 240 (98) | 90 (98) | 130 (93) | 230 (98)* | 2 (67) | 89 (94) |
Cortical thickness | 232 (95) | 88 (96) | 119 (85) | 200 (85) | 2 (67) | 88 (93) |