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Table 2 Performance of the three different assessment sections in discriminating between Alzheimer disease and frontotemporal dementia in terms of diagnostic confidence of Alzheimer disease

From: The impact of transcranial magnetic stimulation on diagnostic confidence in patients with Alzheimer disease

Indices of separation

Clinical work-up

Clinical work-up plus amyloid markers

Clinical work-up plus TMS markers

Cluster mean

Mean (95% CI)

p Value

Mean (95% CI)

p Value

Mean (95% CI)

p Value

 AD cluster

75.0 (73.4–76.6)

p < 1.0 × 10− 5

87.1 (85.2–89.0)

p < 1.0 × 10− 7

89.3 (87.9–90.7)

p < 1.0 × 10− 10

 FTD cluster

19.9 (18.2–21.6)

11.1 (9.0–13.2)

9.3 (7.6–10.9)

AD vs FTD cluster centroid distance

55.1

76.0

80.0

  1. Abbreviations: AD Alzheimer disease, FTD Frontotemporal dementia, TMS Transcranial magnetic stimulation
  2. DCAD mean (and 95% CI) of the two clusters correspond to the means of the two estimated Gaussian components of each mixture model. P-value refers to the difference between cluster means within each assessment