AD | FTD | p Value* | |
---|---|---|---|
Patients (number) | 63 | 57 | – |
Age, years | 70.3 ± 7.2 | 64.4 ± 8.5 | p < 0.001 |
Age at onset (years) | 66.9 ± 6.9 | 60.9 ± 7.8 | p < 0.001 |
Sex (% female) | 52.4 | 42.1 | n.s. |
Education (years) | 10.1 ± 4.7 | 10.2 ± 4.5 | n.s. |
MMSE | 22.8 ± 5.6 | 24.2 ± 6.3 | n.s. |
CDR | 0.9 ± 0.5 | 0.9 ± 0.6 | n.s. |
NPI | 10.9 ± 8.4 | 16.8 ± 10.6 | p = 0.002 |
Short story | 3.9 ± 3.2 | 8.3 ± 11.0 | p = 0.009 |
Rey figure copy | 19.3 ± 11.7 | 24.8 ± 9.4 | p = 0.022 |
Rey figure recall | 4.0 ± 5.2 | 8.2 ± 6.4 | p = 0.001 |
TMT-A (s) | 179.2 ± 177.5 | 112.8 ± 136.8 | p = 0.053 |
TMT-B (s) | 437.8 ± 152.7 | 345.3 ± 175.4 | p = 0.008 |
Phonemic fluency | 21.6 ± 9.6 | 16.6 ± 10.9 | p = 0.023 |
Semantic fluency | 20.3 ± 12.3 | 32.5 ± 70.2 | n.s. |
Clock-drawing test | 5.5 ± 2.8 | 6.7 ± 2.8 | p = 0.028 |
BADL lost | 0.3 ± 0.9 | 0.6 ± 1.2 | n.s. |
IADL lost | 1.8 ± 2.2 | 1.8 ± 2.3 | n.s. |
Amyloid PET, number positive | 38/38 | 1/7 | p < 0.001 |
Cerebrospinal fluid | |||
t-Tau | 788.2 ± 414.5 | 317.0 ± 177.6 | p < 0.001 |
p-Tau181 | 129.4 ± 213.5 | 44.2 ± 24.1 | p = 0.027 |
Aβ1–42 | 520.3 ± 109.6 | 900.6 ± 291.3 | p < 0.001 |
TMS measures | |||
SICI | 0.29 ± 0.11 | 0.67 ± 0.26 | p < 0.001 |
ICF | 1.41 ± 0.20 | 0.87 ± 0.22 | p < 0.001 |
SAI | 0.84 ± 0.10 | 0.52 ± 0.12 | p < 0.001 |
SICI-ICF/SAI ratio | 0.26 ± 0.11 | 1.67 ± 0.91 | p < 0.001 |