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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Vulnerability and resilience to Alzheimer’s disease: early life conditions modulate neuropathology and determine cognitive reserve

Fig. 1

Proposed timelines illustrating how early life experiences can alter brain and cognitive reserve and impact development of AD neuropathology. Early life period determines rate at which AD neuropathology develops, with early life stress (red) accelerating disease progression, while early life enrichment (green) decreases disease progression. In addition, cognitive reserve of the brain is modulated by early life experiences, thereby determining at what pathological stage the clinical diagnosis of dementia is established. AD: Alzheimer’s disease

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