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Table 3 Unstandardized regression coefficients and model fit indices for all models examining baseline ventricular size on Dementia Rating Scale performance and 2-year change

From: Clinical dementia severity associated with ventricular size is differentially moderated by cognitive reserve in men and women

Models

Intercept

Linear slope

Model fit indices

β

SE

p Value

β

SE

p Value

\( {\upchi}_{\mathrm{M}}^2 \)(dfM)

CFI

RMSEA (90% CI)

SRMR

Independent (n = 510)

− 0.202

0.033

0.000

− 0.085

0.026

0.001

13.258 (6), p = 0.039

0.986

0.049 (0.010–0.085)

0.034

E-CR moderation (n = 510)

− 0.093

0.032

0.004

− 0.049

0.028

0.079

5.582 (7), p = 0.589

1.000

0.000 (0.000–0.047)

0.013

E-CR moderation by sex

 Male (n = 254)

− 0.104

0.041

0.012

− 0.046

0.033

0.167

6.737 (7), p = 0.457

1.000

0.000 (0.000–0.075)

0.035

 Female (n = 256)

− 0.076

0.054

0.159

− 0.046

0.052

0.378

5.499 (8), p = 0.703

1.000

0.000 (0.000–0.056)

0.045

L-CR moderation (n = 499)

− 0.052

0.021

0.014

0.016

0.015

0.296

7.308 (7), p = 0.398

0.999

0.009 (0.000–0.056)

0.012

L-CR moderation by sex

 Male (n = 252)

− 0.033

0.027

0.218

0.015

0.017

0.359

7.265 (7), p = 0.402

0.999

0.012 (0.000–0.079)

0.034

 Female (n = 247)

− 0.086

0.034

0.012

0.010

0.033

0.764

7.200 (8), p = 0.515

1.000

0.000 (0.000–0.070)

0.024

CR-P moderation

      

31.751 (18), p = 0.024

0.973

0.068 (0.025–0.106)

0.058

 (a) Low (n = 133)

− 0.382

0.064

0.000

− 0.127

0.055

0.020

    

 (b) Intermediate (n = 189)

− 0.212

0.052

0.000

− 0.070

0.052

0.177

    

 (c) High (n = 177)

− 0.069

0.048

0.145

− 0.089

0.032

0.005

    

CR-P moderation by sex

 Male

      

32.143 (18), p = 0.021

0.941

0.097 (0.037–0.150)

0.141

  (a) Low (n = 58)

− 0.323

0.080

0.000

− 0.094

0.069

0.171

    

  (b) Intermediate (n = 94)

− 0.107

0.074

0.151

0.011

0.068

0.875

    

  (c) High (n = 100)

− 0.107

0.063

0.091

− 0.048

0.032

0.130

    

 Female

      

12.656 (18), p = 0.817

1.000

0.000 (0.000–0.062)

0.078

  (a) Low (n = 75)

− 0.455

0.103

0.000

− 0.221

0.098

0.024

    

  (b) Intermediate (n = 95)

− 0.308

0.067

0.000

− 0.178

0.079

0.025

    

  (c) High (n = 77)

− 0.026

0.075

0.727

− 0.143

0.065

0.027

    
  1. Abbreviations: β Regression estimate, \( {\chi}_M^2 \) Chi-square test of model fit, dfM Degrees of freedom for model fit, CFI Comparative fix index, CR-P Cognitive reserve panel (E-CR + L-CR), E-CR Early-life cognitive reserve, L-CR Later-life cognitive reserve, RMSEA Root mean square error of approximation, SRMR Standardized root mean square residual