Fig. 8
From: In vivo quantification of neurofibrillary tangles with [18F]MK-6240
Quantification estimates across clinical diagnosis and brain regions. Horizontal bar represents mean. a Total volume of distribution (VT; ml/cm3) values obtained with Logan graphical method using plasma input function in individuals who underwent arterial blood sampling. b Distribution volume ratio (DVR) values obtained with reference Logan method and (c) standardized uptake value ratio values measured between 90 and 110 min (SUVR90–110) in all individuals, both using cerebellar gray matter (GM) as reference region. CN cognitively healthy, MCI mild cognitive impairment, AD Alzheimer’s disease, Inf. inferior, Sup. superior, ACC anterior cingulate cortex, PCC posterior cingulate cortex