Fig. 1
From: In vivo quantification of neurofibrillary tangles with [18F]MK-6240
[18F]MK-6240 autoradiographs of postmortem brain tissues of AD and CN individuals. In vitro autoradiography of postmortem brain tissue from prefrontal (PFC) and hippocampal (Hip) cortices as well as cerebellum and whole hemisphere of Alzheimer’s disease (AD) patients and cognitively healthy (CN) individuals. Similar total uptake was found in cerebellar gray matter (Cer GM) of CN and AD individuals (P = 0.2). AD patients had higher relative uptake (ratio with Cer GM) than CN individuals in PFC and Hip cortices (P < 0.001). Total uptake was measured as photostimulated luminescence units per mm2. NS not significant