Disclosure of amyloid positron emission tomography results to individuals without dementia: a systematic review

Table 2 Overview of theoretical arguments in favor or against amyloid positron emission tomography (PET) result disclosure

		Cognitively normal		Mild cognitive impairment
Category	Arguments	Research	Clinic	Research	Clinic
Pro
Ethical	Patient autonomy	X^10,41	X^10,41	X³⁹	X⁵
Ethical	Evidence of non-maleficence	X^10,40,41	X^10,40,41
Social and legal	Cost and suffering reduction	X³⁸	X³⁸
Social and legal	Favors Alzheimer’s disease prevention	X¹⁰	X¹⁰
Psychological and behavioral	Enables early decision making	X¹⁰,^38,41	X^10,38,41	X³⁹	X⁵
	Clarifying effect of correct diagnosis	X³⁸	X³⁸	X³⁹	X⁵
	Relief related to negative amyloid PET	X^38,41	X^38,41
	Satisfies need for risk information	X⁴¹	X⁴¹
PET imaging characteristics	Amyloid PET imaging is validated			X³⁹
PET imaging characteristics	Clinical significance of amyloid PET				X⁵
Contra
Ethical	Non-maleficence	X^10,38,41	X^10,38,41	X³⁹	X⁵
	Lack of effective intervention	X10,³⁸	X10,³⁸	X³⁹
	Therapeutic misconception	X²	X²
Social and legal	Unwanted personal implications	X^38,41	X^10,38,41		X⁵
Social and legal	Social stigmatization	X^38,41	X^38,41
Psychological and behavioral	Risk of psychological distress	X^10,38,41	X^10,38,41		X⁵
	Risk of false reassurance after negative PET	X^10,41	X^10,41	X³⁹
	Misinterpretation of positive amyloid PET	X⁴¹	X⁴¹
PET imaging characteristics	Challenges related to inconclusive scans	X^10,38	X^10,38		X⁵
	Limited predictive value at level of individual	X^10,41	X^10,41
	Variation on interpretation of PET results	X¹⁰	X¹⁰

ISSN: 1758-9193