Table 1 Demographics and clinical characteristics

Age, yr, mean (SD)

68.4 (8.3)

74.1 (5.6)^a

66.0 (7.4)

73.3 (6.9)^a

Gender, n (%) of males

25 (32.05%)

18 (42.86%)

17 (35.42%)

26 (36.11%)

Education, yr, mean (SD)

12.5 (2.7)

12.1 (2.4)

13.2 (2.3)

11.8 (2.7)^a

CDR, score (% of subjects, number of subjects)

0 (60.2%, 47)

or 0.5 (37.2%, 29)

or 1 (2.6%, 2)

0 (2.4%, 1)

or 0.5 (80.9%, 34)

or 1 (16.7%, 7)

0 (100%, 48)

0.5 (87.5%, 63)

or 1 (12.5%, 9)

MMSE score, mean (SD)

27.8 (2.3)

25.2 (3.7)^a

28.5 (1.4)

25.9 (3.5)^a

APOE ε4 carriers, n (%)

13 (16.67%)

24 (57.14%)^a

11 (22.92%)

26 (36.11%)^a

CSF Aβ_1–42 (pg/ml), mean (SD)

979.9 (196.4)

601.2 (190.0)^a

957.4 (194.0)

774.0 (281.5)^a

CSF tau (pg/ml), mean (SD)

235.1 (104.2)

624.2 (322.4)^a

221.5 (82.9)

471.1 (316.6)^a

CSF P-tau181 (pg/ml), mean (SD)

46.7 (13.4)

90.3 (44.8)^a

45.9 (13.3)

72.7 (40.9)^a

CSF P-tau181/Aβ_1–42, mean (SD)

0.05 (0.01)

0.16 (0.10)^a

0.049 (0.015)

0.114 (0.097)^a

CSF albumin index^b, mean (SD)

5.9 (2.4)

6.4 (2.3)

5.3 (1.9)

6.6 (2.5)^a