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Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia

Fig. 8

Active immunotherapy using tau294–305 epitope to hepatitis B core immunodominant region (T294-HBc) virus-like particle (VLP) vaccine rescued synaptic deficits in Tau.P301S mice. Presynapses in brain of mice treated with or without vaccine and of wild-type (WT) mice were detected by IHC and Western blotting with antisynaptophysin antibody. Synaptophysin in the cortex (a) and the hippocampal CA1 (b), and dentate gyrus (DG) regions (c) was quantified using IPwin5 Image-Pro Plus software, and results are shown in arbitrary units (AU). d Synaptophysin levels detected by Western blot analysis. The Western blotting signals were quantified using IPwin5 Image-Pro Plus software, and GAPDH was used as a control. Scale bar is 200 μm (compared with adjuvant-treated mice; *P < 0.05, **P < 0.01, Student’s t test)

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Alzheimer's Research & Therapy

ISSN: 1758-9193