Fig. 2
Hippocampal volumes of brothers A and B on magnetic resonance imaging (MRI) scans. a Cross-sectional data on the volumes of the left (LHV) and right (RHV) hippocampi of brothers A and B on MRI scans from 2009, when the brothers were 58 and 57 years old, respectively. At this time point, brother A had had an Alzheimer’s disease diagnosis for 2 years. The control group consists of 14 noncarriers without cognitive symptoms. The volumes (in mm3) have been divided by the intracranial volume (ICV) of each subject to correct for differences in head size. b Coronal MRI scans of brother A from 1995 (at the age of 44), 2001 (at the age of 50), 2006 (at the age of 55), and 2009 (at the age of 58)