Fig. 1

Mean adjusted Z-scores for individual proteins per diagnostic group. Shown are box plots of the adjusted Z-scores for individual proteins per diagnostic group as results derived from the GEE analysis with all peptide clusters and the diagnosis × protein interaction. p Values were derived from the analyses stratified according to protein, and pairwise comparisons were performed with post hoc Bonferroni corrections. Inherent to the definition of Z-scores, the mean of the total population is point 0 on the y-axis. *p < 0.05; **p < 0.01, ***p < 0.001. AD Alzheimer’s disease, β ₂ M β₂-Microglobulin, CHGA Chromogranin A, CysC Cystatin C, LysC Lysozyme C, MCI Mild cognitive impairment, NCANP Neurocan core protein, NFASC Neurofascin, NPTX1 Neuronal pentraxin 1, NRXN Neurexin, SCG2 Secretogranin 2, VGF Neurosecretory protein VGF