Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Table 1 Cell lines used in this study

iPSC line name	Clone number	Identifier in the study	Disease	Mutation	Sex	Reference
BIOT-7183-PSEN1	S1	fAD-1	Early-onset fAD	PSEN1 c.265G>C, p.V89L	F	[41]
BIOT-7183-PSEN1	S2	fAD-2	Early-onset fAD	PSEN1 c.265G>C, p.V89L	F	[41]
H234	C5	fAD-3	Early-onset fAD	PSEN1 c.449T>C, p.L150P	M	[42]
H235	C6	fAD-4	Early-onset fAD	PSEN1 c.449T>C, p.L150P	M	–
BIOT-0904-LOAD	S2	sAD-1	Late-onset sAD	Unknown	M	[43]
BIOT-0904-LOAD	S3	sAD-2	Late-onset sAD	Unknown	M	[43]
BIOT-0630-LOAD	S4	sAD-3	Late-onset sAD	Unknown	F	[44]
BIOT-4828-LOAD	S1	sAD-4	Late-onset sAD	Unknown	F	[45]
BIOT-4828-LOAD	S6	sAD-5	Late-onset sAD	Unknown	F	[45]
BIOT-0726-LOAD	S3	sAD-6	Late-onset sAD	Unknown	F	[46]
CTRL1	S9	Ctrl-1	Healthy	–	F	–
CTRL1	S11	Ctrl-2	Healthy	–	F	–
H250	C16	Ctrl-3	Healthy	–	F	–
H256	C6	Ctrl-4	Healthy	–	M	–

Abbreviations: iPSC Induced pluripotent stem cell, LOAD Late-onset Alzheimer’s disease

ISSN: 1758-9193