|
Variables
|
B (95% CI)
|
p Value
|
|---|
|
Intercept
|
−3.08 (−4.70, −1.45)
|
< 0.001
|
|
Log(WMH)
|
−0.35 (−0.89, 0.19)
|
0.206
|
|
Male sex
|
0.54 (0.21, 0.87)
|
0.002
|
|
Having at least one APOE ε4 allele
|
−0.36 (−0.71, −0.01)
|
0.042
|
|
Having ABCA7 risk allele
|
0.38 (0.04, 0.72)
|
0.03
|
|
Aβ42
|
0.003 (0.001, 0.004)
|
< 0.001
|
|
t-Tau
|
−0.006 (−0.010, −0.002)
|
0.003
|
|
Age
|
0.039 (0.015, 0.063)
|
0.002
|
|
African American race × log(WMH)
|
−0.496 (−1.074, 0.081)
|
0.091
|
-
Abbreviations: Aβ42 β-Amyloid 1–42, APOE Apolipoprotein E, t-Tau Total tau, WMH White matter hyperintensity
- A stepwise regression model was used to determine factors most strongly associated with cognitive function as reflected by cognitive Z-scores. African American race had a trend of worsening cognitive functioning for the same degree of change in WMH. If the log(WMH) term was removed from this model, African American race was associated with lower cognitive Z-score (by 0.496; p = 0.006) per unit change of log(WMH). Race and sex were not significant factors in this model. Similar results were obtained when p-tau181 instead of t-tau was entered into the model
