Skip to main content

Table 2 Demographic and biomarker variables that influence cognitive Z-scores

From: Race modifies the relationship between cognition and Alzheimer’s disease cerebrospinal fluid biomarkers

Variables B (95% CI) p Value
Intercept −3.08 (−4.70, −1.45) < 0.001
Log(WMH) −0.35 (−0.89, 0.19) 0.206
Male sex 0.54 (0.21, 0.87) 0.002
Having at least one APOE ε4 allele −0.36 (−0.71, −0.01) 0.042
Having ABCA7 risk allele 0.38 (0.04, 0.72) 0.03
Aβ42 0.003 (0.001, 0.004) < 0.001
t-Tau −0.006 (−0.010, −0.002) 0.003
Age 0.039 (0.015, 0.063) 0.002
African American race × log(WMH) −0.496 (−1.074, 0.081) 0.091
  1. Abbreviations: Aβ42 β-Amyloid 1–42, APOE Apolipoprotein E, t-Tau Total tau, WMH White matter hyperintensity
  2. A stepwise regression model was used to determine factors most strongly associated with cognitive function as reflected by cognitive Z-scores. African American race had a trend of worsening cognitive functioning for the same degree of change in WMH. If the log(WMH) term was removed from this model, African American race was associated with lower cognitive Z-score (by 0.496; p = 0.006) per unit change of log(WMH). Race and sex were not significant factors in this model. Similar results were obtained when p-tau181 instead of t-tau was entered into the model
\