Fig. 3

Boxplot of specificities at a given sensitivity of 85% for the different predictor combinations. AUC were calculated by 100 replications of a .632 bootstrapping algorithm. p-values for comparing specificities at the given sensitivity demonstrated the single value predictors HCV and total tau were significantly inferior compared to the two-four predictor combinations. None of the predictor combinations were significantly different from each other. CDR.SB Clinical Dementia Rating–sum-of-boxes, HIPPO hippocampal volume, ttau total tau, ratio42_40 amyloid-beta_1–42/amyloid-beta_1–42 ratio