Brain structures | Cortex | Hippocampus | ||||||
---|---|---|---|---|---|---|---|---|
Injections | NaCl | Aβ42 | NaCl | Aβ42 | ||||
Diets | OLE | ARA | OLE | ARA | OLE | ARA | OLE | ARA |
Phosphatidylinositol | ||||||||
16:0/20:4 | 13.10 ± 1.83 | 13.69 ± 0.33 | 7.80 ± 0.49a | 8.28 ± 0.17a | 10.90 ± 0.49 | 10.49 ± 0.66 | 8.08 ± 2.24 | 7.04 ± 0.21 |
18:0/20:4 | 74.30 ± 1.74 | 76.34 ± 1.37 | 87.32 ± 1.53b | 87.22 ± 0.44b | 78.38 ± 0.56 | 78.17 ± 0.93 | 83.32 ± 3.22 | 83.49 ± 0.54 |
18:1/20:4 | 9.27 ± 0.23 | 7.81 ± 0.97 | 2.95 ± 1.09b | 3.06 ± 0.30a | 9.16 ± 0.32 | 9.77 ± 0.52 | 7.61 ± 0.83 | 7.61 ± 0.42 |
16:0/22:6 | 1.07 ± 0.16 | 0.18 ± 0.04c | 0.18 ± 0.01d | 0.22 ± 0.03 | 0.58 ± 0.02 | 0.53 ± 0.04 | 0.48 ± 0.05 | 0.64 ± 0.01 |
18:0/22:6 | 2.26 ± 0.40 | 1.98 ± 0.25 | 1.75 ± 0.08 | 1.22 ± 0.06 | 0.99 ± 0.09 | 1.04 ± 0.18 | 0.51 ± 0.13 | 1.22 ± 0.74 |
Arachidonic acid species | 96.67 ± 0.57 | 97.84 ± 0.21 | 98.07 ± 0.07 | 98.56 ± 0.06 | 98.43 ± 0.08 | 98.42 ± 0.17 | 99.01 ± 0.17 | 98.14 ± 0.75 |
Docosahexaenoic acid species | 3.33 ± 0.57 | 2.16 ± 0.21 | 1.93 ± 0.07 | 1.44 ± 0.06 | 1.57 ± 0.08 | 1.58 ± 0.17 | 0.99 ± 0.17 | 1.86 ± 0.75 |
Phosphatidylcholine | ||||||||
16:0/20:4 | 45.18 ± 4.90 | 49.97 ± 2.51 | 45.35 ± 1.57 | 53.01 ± 2.76 | 26.94 ± 1.44 | 28.66 ± 1.42 | 68.63 ± 1.96b | 63.14 ± 9.83a |
18:0/20:4 | 16.75 ± 3.75 | 15.2 ± 2.63 | 27.70 ± 2.36 | 26,79 ± 1.59 | 35.68 ± 0.24 | 37.78 ± 1.18 | 16.35 ± 2.13a | 15.05 ± 6.23b |
18:1/20:4 | 2.92 ± 0.76 | 3.38 ± 0.65 | 5.55 ± 0.95 | 3.69 ± 0.22 | 10.29 ± 0.61 | 10.23 ± 0.71 | 2.62 ± 0.28d | 4.83 ± 0.94b |
18:0/22:6 | 16.29 ± 1.27 | 16.30 ± 1.56 | 1.02 ± 0.07d | 2.45 ± 0.50d | 9.05 ± 0.83 | 7.16 ± 0.57 | 5.19 ± 0.83 | 6.81 ± 1.35 |
18:1/22:6 | 8.22 ± 1.40 | 6.80 ± 0.86 | 0.91 ± 0.15b | 1.40 ± 0.22a | 3.04 ± 0.36 | 2.90 ± 0.05 | 3.84 ± 0.47 | 3.10 ± 0.07 |
16:0/22:6 | 10.64 ± 3.33 | 8.43 ± 1.81 | 19.47 ± 0.25 | 12.65 ± 1.95 | 15.00 ± 1.33 | 13.27 ± 0.37 | 3.37 ± 1.33d | 7.07 ± 1.37a |
Arachidonic acid species | 64.85 ± 0.80 | 68.46 ± 1.04 | 78.60 ± 0.15d | 83.49 ± 1.45d | 72.91 ± 2.09 | 76.67 ± 0.97 | 87.61 ± 0.14b | 83.02 ± 2.66 |
Docosahexaenoic acid species | 35.15 ± 0.80 | 31.54 ± 1.04 | 21.40 ± 0.15d | 16.51 ± 1.45d,e | 27.09 ± 2.09 | 23.33 ± 0.97 | 12,39 ± 0.14b | 16.98 ± 2.66 |
Phosphatidylserine | ||||||||
18:0/20:4 | 3.18 ± 0.26 | 11.16 ± 0.35c | 1.47 ± 0.08b | 1,92 ± 0.07d | 6.17 ± 0.23 | 7.12 ± 0.40 | 3.70 ± 0.16b | 5.36 ± 0.37a,e |
16:0/22:4 | 0.13 ± 0.02 | 0.17 ± 0.01 | 0.21 ± 0.01 | 0.22 ± 0.03 | 0.21 ± 0.02 | 0.26 ± 0.03 | 0.077 ± 0.010b | 0.093 ± 0.009b |
18:0/22:4 | 6.35 ± 0.26 | 9.11 ± 0.18c | 5.41 ± 0.14 | 9.10 ± 0.35c | 7.73 ± 0.36 | 10.57 ± 0.03 | 6.31 ± 0.32 | 10.75 ± 1.35e |
18:1/22:5 | 0.43 ± 0.07 | 0.46 ± 0.01 | 0.38 ± 0.08 | 0,45 ± 0.02 | 0.41 ± 0.02 | 0.48 ± 0.06 | 0,41 ± 0.04 | 0.44 ± 0.01 |
18:0/22:6 | 89.91 ± 0.40 | 79.10 ± 0.53c | 92.53 ± 0.19a | 88.32 ± 0.40c,d | 85.49 ± 0.58 | 81.57 ± 0.43 | 89.50 ± 0.46 | 83.35 ± 1.69e |
Phosphatidylethanolamine | ||||||||
a16:0/20:4 | 3.23 ± 0.04 | 4.04 ± 0.07 | 1.70 ± 0.24b | 2.80 ± 0.16b,e | 3.51 ± 0.09 | 4.17 ± 0.15 | 2.74 ± 0.13 | 4,54 ± 0.99 |
p16:0/20:4 | 3.58 ± 0.19 | 4.02 ± 0.04 | 1.06 ± 0.01d | 2.39 ± 0.14c,d | 2.41 ± 0.28 | 2.39 ± 0.16 | 1.59 ± 0.08 | 2,67 ± 0.51 |
a18:0/20:4 | 18.29 ± 1.66 | 16.97 ± 0.26 | 18.03 ± 0.16 | 19.38 ± 0.44 | 20.52 ± 0.36 | 21.31 ± 0.96 | 22.66 ± 0.65 | 13.57 ± 5.29 |
p18:0/20:4 | 4.70 ± 0.19 | 5.78 ± 0.24 | 5.12 ± 0.24 | 6.43 ± 0.09e | 4.45 ± 0.31 | 5.02 ± 0.30 | 4.93 ± 0.19 | 8.68 ± 1.91 |
a18:1/20:4 | 2.22 ± 0.11 | 2.38 ± 0.06 | 0.41 ± 0.09d | 0.84 ± 0.08d,e | 2.47 ± 0.06 | 2.84 ± 0.03 | 1.18 ± 0.07b | 1.17 ± 0.36b |
p18:1/20:4 | 2.79 ± 0.18 | 3.20 ± 0.08 | 1.21 ± 0.23b | 2.13 ± 0.10b,e | 2.50 ± 0.17 | 2.87 ± 0.21 | 4.22 ± 0.95 | |
a18:2/20:4 | 0.03 ± 0.01 | 0.04 ± 0.005 | 0.02 ± 0.001 | 0.02 ± 0.003 | 0 | 0 | 0.025 ± 0.001b | 0.014 ± 0.010 |
p18:2/20:4 | 0.04 ± 0.004 | 0.03 ± 0.004 | 0.02 ± 0.004 | 0.02 ± 0.002 | 0.048 ± 0.007 | 0 | 0.032 ± 0.004b | 0.031 ± 0.008a |
p16:0/22:4 | 3.15 ± 0.14 | 3.76 ± 0.15 | 2,91 ± 0.24 | 4,29 ± 0.08f | 3.12 ± 0.33 | 3.71 ± 0.13 | 3.67 ± 0.05 | 6.13 ± 1.29 |
p16:1/22:4 | 0 | 0.01 ± 0.00 | 0.0015 ± 0.0007 | 0.0029 ± 0.0003b | 0 | 0 | 0.0033 ± 0.0005 | 0,006 ± 0.0016a |
a18:0/22:4 | 3.97 ± 0.41 | 4.51 ± 0.24 | 1.55 ± 0.06d | 2.25 ± 0.11b | 3.02 ± 0.01 | 3.78 ± 0.29 | 1.94 ± 0.11 | 4.34 ± 0.71e |
a18:1/22:4 | 0.21 ± 0.01 | 0.26 ± 0.01e | 0.10 ± 0.01d | 0.20 ± 0.002a,c | 0.22 ± 0.06 | 0.28 ± 0.01 | 0.17 ± 0.01 | 0,35 ± 0.08e |
a18:0/22:5 | 7.13 ± 0.57 | 7.20 ± 0.09 | 5.19 ± 0.21a | 5.85 ± 0.12 | 4.47 ± 0.15 | 5.23 ± 0.10 | 5.26 ± 0.09 | 6,67 ± 1.70 |
a16:0/22:6 | 7.10 ± 0.14 | 6.24 ± 0.06f | 4.03 ± 0.06d | 3.71 ± 0.06d | 5.89 ± 0.01 | 5.49 ± 0.24 | 3.85 ± 0.05 | 1.12 ± 0.80b,e |
p16:0/22:6 | 6.02 ± 0.15 | 4.69 ± 0.14f | 3.62 ± 0.17d | 2.74 ± 0.06d,e | 4.90 ± 0.40 | 5.46 ± 0.09 | 4.29 ± 0.21 | 4,90 ± 0.72 |
a18:0/22:6 | 28.25 ± 3.25 | 22.01 ± 0.55 | 25.14 ± 0.42 | 22.31 ± 0.06 | 20.70 ± 0.42 | 17.94 ± 0.37 | 22.28 ± 0.27 | 23.27 ± 6.20 |
p18:0/22:6 | 11.76 ± 1.53 | 10.31 ± 0.51 | 16,14 ± 0.46 | 13.10 ± 0.61 | 16.72 ± 1.60 | 14.60 ± 0.99 | 17.65 ± 1.01 | 9,16 ± 3.54 |
a18:1/22:6 | 2.03 ± 0.29 | 1.36 ± 0.05 | 12.66 ± 1.05d | 10.33 ± 0.79d | 1.55 ± 0.16 | 1.27 ± 0.04 | 5,32 ± 1.00b | 1,18 ± 0.23f |
p18:1/22:6 | 3.34 ± 0.13 | 3.19 ± 0.16 | 1.11 ± 0.23d | 1.19 ± 0.08d | 4.13 ± 0.31 | 3.64 ± 0.22 | 2,43 ± 0.37 | 1.61 ± 0.55a |
Arachidonic acid species | 30.11 ± 3.0 | 36.46 ± 0.09 | 27.56 ± 0.94 | 34.02 ± 0.69 | 35.92 ± 0.44 | 38.60 ± 1.27 | 33,16 ± 0.32 | 41.28 ± 6.36 |
Docosahexaenoic acid species | 56.49 ± 3.17 | 47.80 ± 0.24e | 62,69 ± 0.93 | 53,39 ± 0.73e | 53.25 ± 0.95 | 48.40 ± 1.35 | 55.81 ± 0.33 | 41.23 ± 2.85f |
Docosatetraenoic acid species | 6.27 ± 0.64 | 8.53 ± 0.11e | 4,56 ± 0.21 | 6.74 ± 0.16a,e | 6.36 ± 0.36 | 7.77 ± 0.27 | 5.78 ± 0.08 | 10.83 ± 2.07 |
Docosapentaenoic acid species | 7.13 ± 0.57 | 7.20 ± 0.09 | 5,19 ± 0.21a | 5.85 ± 0.12 | 4.47 ± 0.15 | 5.23 ± 0.10 | 5.26 ± 0.09 | 6.67 ± 1.70 |