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Table 4 Brain phospholipids (percentage of measured phospholipids for each class) among male mice fed oleic acid-enriched or arachidonic acid-enriched diet

From: Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance

Brain structures

Cortex

Hippocampus

Injections

NaCl

42

NaCl

42

Diets

OLE

ARA

OLE

ARA

OLE

ARA

OLE

ARA

Phosphatidylinositol

 16:0/20:4

13.10 ± 1.83

13.69 ± 0.33

7.80 ± 0.49a

8.28 ± 0.17a

10.90 ± 0.49

10.49 ± 0.66

8.08 ± 2.24

7.04 ± 0.21

 18:0/20:4

74.30 ± 1.74

76.34 ± 1.37

87.32 ± 1.53b

87.22 ± 0.44b

78.38 ± 0.56

78.17 ± 0.93

83.32 ± 3.22

83.49 ± 0.54

 18:1/20:4

9.27 ± 0.23

7.81 ± 0.97

2.95 ± 1.09b

3.06 ± 0.30a

9.16 ± 0.32

9.77 ± 0.52

7.61 ± 0.83

7.61 ± 0.42

 16:0/22:6

1.07 ± 0.16

0.18 ± 0.04c

0.18 ± 0.01d

0.22 ± 0.03

0.58 ± 0.02

0.53 ± 0.04

0.48 ± 0.05

0.64 ± 0.01

 18:0/22:6

2.26 ± 0.40

1.98 ± 0.25

1.75 ± 0.08

1.22 ± 0.06

0.99 ± 0.09

1.04 ± 0.18

0.51 ± 0.13

1.22 ± 0.74

 Arachidonic acid species

96.67 ± 0.57

97.84 ± 0.21

98.07 ± 0.07

98.56 ± 0.06

98.43 ± 0.08

98.42 ± 0.17

99.01 ± 0.17

98.14 ± 0.75

 Docosahexaenoic acid species

3.33 ± 0.57

2.16 ± 0.21

1.93 ± 0.07

1.44 ± 0.06

1.57 ± 0.08

1.58 ± 0.17

0.99 ± 0.17

1.86 ± 0.75

 Phosphatidylcholine

 16:0/20:4

45.18 ± 4.90

49.97 ± 2.51

45.35 ± 1.57

53.01 ± 2.76

26.94 ± 1.44

28.66 ± 1.42

68.63 ± 1.96b

63.14 ± 9.83a

 18:0/20:4

16.75 ± 3.75

15.2 ± 2.63

27.70 ± 2.36

26,79 ± 1.59

35.68 ± 0.24

37.78 ± 1.18

16.35 ± 2.13a

15.05 ± 6.23b

 18:1/20:4

2.92 ± 0.76

3.38 ± 0.65

5.55 ± 0.95

3.69 ± 0.22

10.29 ± 0.61

10.23 ± 0.71

2.62 ± 0.28d

4.83 ± 0.94b

 18:0/22:6

16.29 ± 1.27

16.30 ± 1.56

1.02 ± 0.07d

2.45 ± 0.50d

9.05 ± 0.83

7.16 ± 0.57

5.19 ± 0.83

6.81 ± 1.35

 18:1/22:6

8.22 ± 1.40

6.80 ± 0.86

0.91 ± 0.15b

1.40 ± 0.22a

3.04 ± 0.36

2.90 ± 0.05

3.84 ± 0.47

3.10 ± 0.07

 16:0/22:6

10.64 ± 3.33

8.43 ± 1.81

19.47 ± 0.25

12.65 ± 1.95

15.00 ± 1.33

13.27 ± 0.37

3.37 ± 1.33d

7.07 ± 1.37a

 Arachidonic acid species

64.85 ± 0.80

68.46 ± 1.04

78.60 ± 0.15d

83.49 ± 1.45d

72.91 ± 2.09

76.67 ± 0.97

87.61 ± 0.14b

83.02 ± 2.66

 Docosahexaenoic acid species

35.15 ± 0.80

31.54 ± 1.04

21.40 ± 0.15d

16.51 ± 1.45d,e

27.09 ± 2.09

23.33 ± 0.97

12,39 ± 0.14b

16.98 ± 2.66

Phosphatidylserine

 18:0/20:4

3.18 ± 0.26

11.16 ± 0.35c

1.47 ± 0.08b

1,92 ± 0.07d

6.17 ± 0.23

7.12 ± 0.40

3.70 ± 0.16b

5.36 ± 0.37a,e

 16:0/22:4

0.13 ± 0.02

0.17 ± 0.01

0.21 ± 0.01

0.22 ± 0.03

0.21 ± 0.02

0.26 ± 0.03

0.077 ± 0.010b

0.093 ± 0.009b

 18:0/22:4

6.35 ± 0.26

9.11 ± 0.18c

5.41 ± 0.14

9.10 ± 0.35c

7.73 ± 0.36

10.57 ± 0.03

6.31 ± 0.32

10.75 ± 1.35e

 18:1/22:5

0.43 ± 0.07

0.46 ± 0.01

0.38 ± 0.08

0,45 ± 0.02

0.41 ± 0.02

0.48 ± 0.06

0,41 ± 0.04

0.44 ± 0.01

 18:0/22:6

89.91 ± 0.40

79.10 ± 0.53c

92.53 ± 0.19a

88.32 ± 0.40c,d

85.49 ± 0.58

81.57 ± 0.43

89.50 ± 0.46

83.35 ± 1.69e

Phosphatidylethanolamine

 a16:0/20:4

3.23 ± 0.04

4.04 ± 0.07

1.70 ± 0.24b

2.80 ± 0.16b,e

3.51 ± 0.09

4.17 ± 0.15

2.74 ± 0.13

4,54 ± 0.99

 p16:0/20:4

3.58 ± 0.19

4.02 ± 0.04

1.06 ± 0.01d

2.39 ± 0.14c,d

2.41 ± 0.28

2.39 ± 0.16

1.59 ± 0.08

2,67 ± 0.51

 a18:0/20:4

18.29 ± 1.66

16.97 ± 0.26

18.03 ± 0.16

19.38 ± 0.44

20.52 ± 0.36

21.31 ± 0.96

22.66 ± 0.65

13.57 ± 5.29

 p18:0/20:4

4.70 ± 0.19

5.78 ± 0.24

5.12 ± 0.24

6.43 ± 0.09e

4.45 ± 0.31

5.02 ± 0.30

4.93 ± 0.19

8.68 ± 1.91

 a18:1/20:4

2.22 ± 0.11

2.38 ± 0.06

0.41 ± 0.09d

0.84 ± 0.08d,e

2.47 ± 0.06

2.84 ± 0.03

1.18 ± 0.07b

1.17 ± 0.36b

 p18:1/20:4

2.79 ± 0.18

3.20 ± 0.08

1.21 ± 0.23b

2.13 ± 0.10b,e

2.50 ± 0.17

2.87 ± 0.21

 

4.22 ± 0.95

 a18:2/20:4

0.03 ± 0.01

0.04 ± 0.005

0.02 ± 0.001

0.02 ± 0.003

0

0

0.025 ± 0.001b

0.014 ± 0.010

 p18:2/20:4

0.04 ± 0.004

0.03 ± 0.004

0.02 ± 0.004

0.02 ± 0.002

0.048 ± 0.007

0

0.032 ± 0.004b

0.031 ± 0.008a

 p16:0/22:4

3.15 ± 0.14

3.76 ± 0.15

2,91 ± 0.24

4,29 ± 0.08f

3.12 ± 0.33

3.71 ± 0.13

3.67 ± 0.05

6.13 ± 1.29

 p16:1/22:4

0

0.01 ± 0.00

0.0015 ± 0.0007

0.0029 ± 0.0003b

0

0

0.0033 ± 0.0005

0,006 ± 0.0016a

 a18:0/22:4

3.97 ± 0.41

4.51 ± 0.24

1.55 ± 0.06d

2.25 ± 0.11b

3.02 ± 0.01

3.78 ± 0.29

1.94 ± 0.11

4.34 ± 0.71e

 a18:1/22:4

0.21 ± 0.01

0.26 ± 0.01e

0.10 ± 0.01d

0.20 ± 0.002a,c

0.22 ± 0.06

0.28 ± 0.01

0.17 ± 0.01

0,35 ± 0.08e

 a18:0/22:5

7.13 ± 0.57

7.20 ± 0.09

5.19 ± 0.21a

5.85 ± 0.12

4.47 ± 0.15

5.23 ± 0.10

5.26 ± 0.09

6,67 ± 1.70

 a16:0/22:6

7.10 ± 0.14

6.24 ± 0.06f

4.03 ± 0.06d

3.71 ± 0.06d

5.89 ± 0.01

5.49 ± 0.24

3.85 ± 0.05

1.12 ± 0.80b,e

 p16:0/22:6

6.02 ± 0.15

4.69 ± 0.14f

3.62 ± 0.17d

2.74 ± 0.06d,e

4.90 ± 0.40

5.46 ± 0.09

4.29 ± 0.21

4,90 ± 0.72

 a18:0/22:6

28.25 ± 3.25

22.01 ± 0.55

25.14 ± 0.42

22.31 ± 0.06

20.70 ± 0.42

17.94 ± 0.37

22.28 ± 0.27

23.27 ± 6.20

 p18:0/22:6

11.76 ± 1.53

10.31 ± 0.51

16,14 ± 0.46

13.10 ± 0.61

16.72 ± 1.60

14.60 ± 0.99

17.65 ± 1.01

9,16 ± 3.54

 a18:1/22:6

2.03 ± 0.29

1.36 ± 0.05

12.66 ± 1.05d

10.33 ± 0.79d

1.55 ± 0.16

1.27 ± 0.04

5,32 ± 1.00b

1,18 ± 0.23f

 p18:1/22:6

3.34 ± 0.13

3.19 ± 0.16

1.11 ± 0.23d

1.19 ± 0.08d

4.13 ± 0.31

3.64 ± 0.22

2,43 ± 0.37

1.61 ± 0.55a

 Arachidonic acid species

30.11 ± 3.0

36.46 ± 0.09

27.56 ± 0.94

34.02 ± 0.69

35.92 ± 0.44

38.60 ± 1.27

33,16 ± 0.32

41.28 ± 6.36

 Docosahexaenoic acid species

56.49 ± 3.17

47.80 ± 0.24e

62,69 ± 0.93

53,39 ± 0.73e

53.25 ± 0.95

48.40 ± 1.35

55.81 ± 0.33

41.23 ± 2.85f

 Docosatetraenoic acid species

6.27 ± 0.64

8.53 ± 0.11e

4,56 ± 0.21

6.74 ± 0.16a,e

6.36 ± 0.36

7.77 ± 0.27

5.78 ± 0.08

10.83 ± 2.07

 Docosapentaenoic acid species

7.13 ± 0.57

7.20 ± 0.09

5,19 ± 0.21a

5.85 ± 0.12

4.47 ± 0.15

5.23 ± 0.10

5.26 ± 0.09

6.67 ± 1.70

  1. 42 Amyloid-β peptide 42, ARA Arachidonic acid-enriched diet, OLE Oleic acid-enriched diet
  2. a p < 0.05, Aβ42 compared with NaCl
  3. b p < 0.01, Aβ42 compared with NaCl
  4. c p < 0.001, ARA compared with OLE
  5. d p < 0.001, Aβ42 compared with NaCl
  6. e p < 0.05, ARA compared with OLE
  7. f p < 0.01, ARA compared with OLE