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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

Fig. 5

Effects of diverse forms of soluble Aβ aggregates on cognitive performance after intracerebroventricular injection in rats. Reproduced from Figure 4 of Reed et al. [54]. Perseveration errors refer to effects on alternative lever cyclic ratio testing after training to a stable baseline performance. Total Aβ was measured by western blotting with a mixture of Aβ40- and Aβ42-specific antibodies. Unfractionated 7PA2 cell lysates (7PA2 DEC) were more potent than fractionated lysates, synthetic oligomers, or species isolated from transgenic Tg2576 mice [33, 61]

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