Associations of thyroid hormone serum levels with in-vivo Alzheimer’s disease pathologies

Table 2 Multiple linear regression analysis with global cerebral Aβ deposition as the dependent variable (n = 148)

Dependent variable	Independent variable	Model I^a				Model II^b
		B	SE	t	p	B	SE	t	p
Global cerebral Aβ deposition	Serum fT4 level	– 0.213	0.088	– 2.407	0.017*	– 0.205	0.088	– 2.316	0.022*

Multiple linear regression analysis was conducted to investigate the relationship between serum fT4 level and global cerebral Aβ deposition controlling for several variables. Global Aβ deposition values were natural log-transformed to normalize variance
Aβ amyloid beta protein, APOE apolipoprotein E, B regression coefficient, SE standard error, fT4 free thyroxine
*p < 0.025 (statistically significant)
^aAdjusted for age, gender, and APOE ε4 carrier status
^bAdjusted for age, gender, APOE ε4 carrier status, and vascular risk score

ISSN: 1758-9193