bvFTD (n = 26) | AD (n = 43) | bvFTD vs. AD | Classification as bvFTD vs. AD | |
---|---|---|---|---|
Mean (SD) | Mean (SD) | t(df) | ||
Demographics | ||||
Age, years | 65 (8) | 72 (9) | 3.44 (67)a | |
Education, years | 11 (1.7) | 11 (1.8) | −0.98 (67) | |
Sex, M/F | 21/5 | 17/26 | N/A | |
Disease severity scores | ||||
MMSE | 26 (3) | 24 (3) | −2.48 (67)b | |
FBI | 28 (10) | N/A | N/A | |
Disease duration, months | 29 (19) | 23 (14) | −1.40 (67) | |
Total amyloid-β | 850 (424) | 397 (108) | −4.16 (61)a | |
Total tau protein | 403 (256) | 756 (277) | 4.07 (61)a | |
Neuropsychological assessment | ||||
Memory | ||||
Verbal span | −0.77 (0.98) | −1.47 (0.99) | −2.88 (67)b | |
Verbal learning | −1.54 (1.32) | −2.36 (1.11) | −2.77 (67)b | |
Verbal recall | −1.74 (1.25) | −2.98 (0.77) | −5.1 (67)a | 0.613 |
Verbal recognition | −0.77 (1.74) | −4.14 (5.25) | −3.88 (67)a | |
Visual recall | −0.74 (0.95) | −1.34 (0.90) | −2.62 (67)b | |
Language | ||||
Object naming | −0.16 (0.94) | −1.06 (1.55) | −2.99 (67)b | |
Visuospatial skills | ||||
Figure copy | 0.16 (1.05) | −1.05 (1.85) | −3.48 (67)a | 0.300 |
Executive functions | ||||
Semantic word fluency | −1.11 (0.98) | −1.21 (1.05) | −0.43 (67) | |
Phonematic word fluency | −1.13 (0.88) | −0.58 (1.14) | 2.08 (67) | |
Set shifting | −1.50 (1.90) | −3.18 (2.15) | −3.18 (67)a | |
Digit span backwards | −1.29 (1.39) | −1.71 (1.23) | −1.26 (67) | |
Attention | ||||
Processing speed | −0.90 (2.31) | −3.48 (3.73) | −3.41 (67)a | |
Praxis | ||||
Pantomime of object use | −2.51 (2.04) | −5.21 (5.90) | −2.17 (67)b | |
Imitation of limb postures | −2.80 (3.41) | −5.39 (4.61) | −2.45 (67)b | 0.299 |
Imitation of face postures | −4.88 (4.04) | −2.00 (2.50) | 3.33 (67)a | −0.512 |
Social cognition | ||||
Facial emotion recognition | −2.35 (2.41) | −1.96 (2.10) | 0.58 (67) |