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Table 2 Demographic, clinical and cognitive data of patients with behavioural variant of frontotemporal dementia and patients with Alzheimer’s disease at initial clinical presentation

From: Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?

 

bvFTD (n = 26)

AD (n = 43)

bvFTD vs. AD

Classification as bvFTD vs. AD

Mean (SD)

Mean (SD)

t(df)

Demographics

 Age, years

65 (8)

72 (9)

3.44 (67)a

 

 Education, years

11 (1.7)

11 (1.8)

−0.98 (67)

 Sex, M/F

21/5

17/26

N/A

Disease severity scores

 MMSE

26 (3)

24 (3)

−2.48 (67)b

 

 FBI

28 (10)

N/A

N/A

 Disease duration, months

29 (19)

23 (14)

−1.40 (67)

 Total amyloid-β

850 (424)

397 (108)

−4.16 (61)a

 Total tau protein

403 (256)

756 (277)

4.07 (61)a

Neuropsychological assessment

 Memory

  Verbal span

−0.77 (0.98)

−1.47 (0.99)

−2.88 (67)b

 

  Verbal learning

−1.54 (1.32)

−2.36 (1.11)

−2.77 (67)b

  Verbal recall

−1.74 (1.25)

−2.98 (0.77)

−5.1 (67)a

0.613

  Verbal recognition

−0.77 (1.74)

−4.14 (5.25)

−3.88 (67)a

 

  Visual recall

−0.74 (0.95)

−1.34 (0.90)

−2.62 (67)b

 Language

  Object naming

−0.16 (0.94)

−1.06 (1.55)

−2.99 (67)b

 

 Visuospatial skills

  Figure copy

0.16 (1.05)

−1.05 (1.85)

−3.48 (67)a

0.300

 Executive functions

  Semantic word fluency

−1.11 (0.98)

−1.21 (1.05)

−0.43 (67)

 

  Phonematic word fluency

−1.13 (0.88)

−0.58 (1.14)

2.08 (67)

  Set shifting

−1.50 (1.90)

−3.18 (2.15)

−3.18 (67)a

  Digit span backwards

−1.29 (1.39)

−1.71 (1.23)

−1.26 (67)

 Attention

  Processing speed

−0.90 (2.31)

−3.48 (3.73)

−3.41 (67)a

 

 Praxis

  Pantomime of object use

−2.51 (2.04)

−5.21 (5.90)

−2.17 (67)b

 

  Imitation of limb postures

−2.80 (3.41)

−5.39 (4.61)

−2.45 (67)b

0.299

  Imitation of face postures

−4.88 (4.04)

−2.00 (2.50)

3.33 (67)a

−0.512

 Social cognition

  Facial emotion recognition

−2.35 (2.41)

−1.96 (2.10)

0.58 (67)

 
  1. Abbreviations: AD Alzheimer’s disease, bvFTD Behavioural variant of frontotemporal dementia, FBI Frontal Behavioral Inventory, MMSE Mini Mental State Examination, N/A Not applicable
  2. Column 1 displays all demographic and clinical categories, cognitive domains and respective standardised subdomains. Columns 2 and 3 display group means and SDs of demographic and clinical categories and of the z-transformed cognitive subdomain scores (refer to Table 1). Column 4 displays the test statistical values resulting from group comparison analysis (Student’s t test). Column 5 displays the standardised canonical discriminant function coefficients resulting from discriminant function analysis. Higher values indicate major importance for successful group classification
  3. aSignificant difference at p < 0.003 (Bonferroni correction for number of cognitive tests)
  4. bSignificant difference at p < 0.05