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Table 3 Unadjusted regression coefficients of MMSE, IADL, and NPI for each anticholinergic scale and total number of drugs (one model for each covariable)

From: Anticholinergic drugs and functional, cognitive impairment and behavioral disturbances in patients from a memory clinic with subjective cognitive decline or neurocognitive disorders

 

Outcome 1: MMSE

Outcome 2: IADL

Outcome 3: NPI

Covariable

r (95% CI)

Standardized r

p value

R 2

r (95% CI)

Standardized r

p value

R 2

r (95% CI)

Standardized r

p value

R 2

ACB

–0.22 (–0.69 to 0.25)

–0.04

0.36

0.2%

–0.27 (–0.45 to –0.09)

–0.14

0.003

1.6%

1.13 (0.04 to 2.21)

0.10

0.04

1%

ADS

–0.37 (–1.00 to 0.26)

–0.06

0.25

0.3%

–0.32 (–0.56 to –0.08)

–0.12

0.009

1.3%

1.08 (–0.36 to 2.53)

0.07

0.14

0.5%

ARS

–0.08 (–0.97 to 0.82)

–0.01

0.86

<0.1%

–0.37 (–0.71 to –0.04)

–0.10

0.03

0.8%

0.52 (–1.50 to 2.53)

0.03

0.62

0.1%

Chew’s score

–0.05 (–0.47 to 0.37)

–0.01

0.81

<0.1%

–0.30 (–0.46 to –0.14)

–0.17

<0.001

2.5%

0.57 (–0.37 to 1.51)

0.06

0.23

0.3%

Han’s score

–0.68 (–1.34 to –0.02)

–0.10

0.04

0.7%

–0.37 (–0.62 to –0.12)

–0.13

0.004

1.6%

1.85 (0.40 to 3.30)

0.12

0.01

1.5%

Number of drugs with AC properties

–0.51 (–0.85 to –0.18)

–0.14

0.003

2%

–0.35 (–0.48 to –0.23)

–0.25

<0.001

6.1%

1.17 (0.43 to 1.91)

0.15

0.002

2.3%

Total number of drugs

0.02 (–0.20 to 0.25)

0.01

0.83

<0.1%

–0.11 (–0.19 to –0.02)

–0.11

0.02

1.2%

0.81 (0.31 to 1.32)

0.16

0.002

2.4%

  1. AC anticholinergic, ACB Anticholinergic Cognitive Burden, ADS Anticholinergic Drug Scale, ARS Anticholinergic Risk Scale, CI confidence interval, IADL Instrumental Activities of Daily Living, MMSE Mini Mental State Examination, NPI Neuropsychiatric Inventory, r Regression coefficient, R² Coefficient of determination