Association between chronic periodontitis and the risk of Alzheimer’s disease: a retrospective, population-based, matched-cohort study

Table 1 Demographic characteristics of the study cohort at baseline

Variable	Total		Chronic periodontitis				p value
			With		Without
	n	%	n	%	n	%
Total	27,963	100	9291	100	18,672	100
Sex
Female	13,119	46.92	4351	46.83	8768	46.96	0.8402
Male	14,844	53.08	4940	53.17	9904	53.04
Age, years
50–59	13,947	49.88	4638	49.92	9309	49.86	0.9705
60–69	8853	31.66	2945	31.70	5908	31.64
≥70	5163	18.46	1708	18.38	3455	18.50
Hypertension
No	6654	23.80	2251	24.23	4403	23.58	0.2314
Yes	21,309	76.20	7040	75.77	14,269	76.42
Hyperlipidaemia
No	21,651	77.43	6935	74.64	14,716	78.81	<0.0001
Yes	6312	22.57	2356	25.36	3956	21.19
Chronic kidney disease
No	17,243	61.66	5697	61.32	11,546	61.84	0.4009
Yes	10,720	38.34	3594	38.68	7126	38.16
Depression
No	23,283	83.26	7619	82.00	15,664	83.89	<0.0001
Yes	4680	16.74	1672	18.00	3008	16.11
Stroke
No	21,316	76.23	7081	76.21	14,235	76.24	0.9652
Yes	6647	23.77	2210	23.79	4437	23.76
Diabetes mellitus
No	14,545	52.02	4627	49.8	9918	53.12	<0.0001
Yes	13,418	47.98	4664	50.2	8754	46.88
Traumatic brain injury
No	22,517	80.52	7562	81.39	14,955	80.09	0.0099
Yes	5446	19.48	1729	18.61	3717	19.91
CCI score
0	17,032	60.91	6423	69.13	10,609	56.82	<0.0001
1	7826	27.99	2206	23.74	5620	30.10
2	3105	11.10	662	7.13	2443	13.08
≥3	1685	6.03	499	5.37	1186	6.35
Urbanisation level
1	2896	10.36	890	9.58	2006	10.74	<0.0001
2	3675	13.14	1219	13.12	2456	13.15
3	19,707	70.48	6683	71.93	13,024	69.75

ISSN: 1758-9193