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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: RETRACTED ARTICLE: Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer’s disease pathogenesis

Fig. 7

Higher Aβ42-α7nAChR complex levels and reduced response to exogenous Aβ42 in lymphocytes from MCI and AD patients correlate with plasma apoE4. Lymphocytes obtained from cognitive normal controls (C), subjects with mild cognitive impairments (MCI), and Alzheimer’s disease (AD) were incubated without or with 0.1 μM Aβ42. The levels of Aβ42-α7nAChR complexes were determined by the abundance of α7nAChRs in the anti-Aβ42 antibody immunoprecipitates by Western blotting (a), quantified by densitometric scanning, and normalized by β-actin immunoreactivity as the immunoprecipitation/loading controls. The data expressed as the ratios of positive Aβ42 to negative Aβ42 (mean ± SEM) summarizes the effects of Aβ42 derived from two separate visits on the Aβ42-α7nAChR association in different diagnostic groups without b and with c segregating by the APOE genotype. *p < 0.01, **p < 0.05, compared to respective cognitive normal group b or APOE ε2/ε3 c by Dunnett’s test adjusted for multiple comparisons. d Correlations between positive plasma to negative plasma ratios in synaptosomes and positive Aβ42 to negative Aβ42 ratios in lymphocytes derived from visit 1 spearman correlation coefficient: controls = 0.17 (–0.25;0.54); MCI = –0.81 (–0.91; –0.62); AD = –0.58 (–0.77; –0.30); all = –0.84 (–0.89; –0.76). e Correlation to longitudinal cognitive changes per evolution of diagnostic group (control not progressed (CTRL NP) and progressed (P), MCI NP and P, and AD), n = 86 including 32 AD, 30 MCI, and 24 control subjects from four distinct APOE genotype groups: controls NP = –0.04 (0.46; 0.40); controls P = NA; MCI NP = –0.08 (–0.61; 0.49); MCI P = –0.10 (–0.57; 0.42); AD = 0.23 (–0.12; 0.53); all = 0.46 (0.28; –0.62). α7nAChR α7-nicotinic acetylcholine receptor, amyloid beta, apoE apolipoprotein, V visit

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