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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels

Fig. 1

MAO-B immunohistochemical staining of thin sections from the frontal cortex of Control (Cntr), FAD and AD brains. a Typical images of the different layers of frontal cortex from one each of a Cntr, FAD and AD case are shown in images taken at 4× magnification. Scale bar, 200 μm. b Layers I–II with plaque staining (blue arrows) in the FAD and AD cases, imaged at 20× magnification. Scale bar, 50 μm. c Layer III with pyramidal neurons that are intensively stained in FAD and AD (20× magnification). Examples of pyramidal neurons shown by red arrows. Note the neurite staining (black arrow). Scale bar, 50 μm. d In the white matter (wm) the density of stained astrocyte-like cells is more intensive in FAD and AD (20× magnification). Scale bar, 50 μm. e Plaques in layers II–III and V surrounded by MAO-B positive cells in FAD and AD (40× magnification). Blue arrows point at plaques. The white balance for the background was adjusted in Photoshop, in a similar manner for all raw images, using a color sample tool and color balance to adjust highlights. Scale bar, 50 μm. AD Alzheimer disease, FAD familial AD (Color figure online)

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Alzheimer's Research & Therapy

ISSN: 1758-9193