Table 1 Half-maximal effective concentrations of J147 and CAD-31 in six assays
From: A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism
Assay | Cell type | J147 (nM) | CAD-31 (nM) |
|---|---|---|---|
Trophic factor withdrawal | Cortical neuron | 35 | 18 |
BDNF-like activity | HT22 | 74 | 95 |
Oxytosis | Cortical neuron | 6 | 20 |
In vitro ischemia | HT22 | 14 | 47 |
Aβ toxicity (extracellular) | Hippocampal neuron | 15 | 27 |
Aβ toxicity (intracellular) | MC65 | 10 | 12 |