| AD panel |  | p-taurel
| Aβ1–42/p-taurel
| p-tau181/p-taurel
|
---|
AD vs. non-AD | p-tau181
| 0.883 | 0.619$
| Â | Â |
Aβ1–42/p-tau181
| 0.860 | Â | 0.657$
| Â |
AD vs. FTLD | p-tau181
| 0.933 | 0.799$
| Â | Â |
Aβ1–42/p-tau181
| 0.920 | Â | 0.846$
| Â |
AD vs. DLB | t-tau | 0.863 | 0.706$
| Â | Â |
Aβ1–42/t-tau | 0.855 |  | 0.747$
| Â |
AD vs. CJD | t-tau | 0.896 | 0.978*
| Â | Â |
p-tau181/t-tau | 1.000 | Â | Â | 1.000 |
AD vs. controls | t-tau | 0.926 | 0.865 | Â | Â |
Aβ1–42/t-tau | 0.976 |  | 0.949 |  |
FTLD vs. controls | Aβ1–42
| 0.679 | 0.588 | Â | Â |
p-tau181/t-tau | 0.827 | Â | Â | 0.695 |
DLB vs. controls | Aβ1–42
| 0.747 | 0.717 | Â | Â |
Aβ1–42/p-tau181
| 0.739 | Â | 0.815 | Â |
CJD vs. controls | t-tau | 0.978 | 1.000 | Â | Â |
Aβ1–42/t-tau | 1.000 |  | 1.000 |  |
- The third column contains AUC values for the established single markers and biomarker ratios with the highest diagnostic value
- Adjacent columns show AUC values of p-taurel and the equivalent ratio using p-taurel
- Significant differences between AUC values (DeLong tests, p < 0.05) are marked by an asterisk (*) when diagnostic power is significantly higher with addition of p-taurel, and by a dollar sign ($) when diagnostic power is significantly lower with addition of p-taurel
-
Aβ
1–42
amyloid-beta of 42 amino acids, AD Alzheimer’s disease, CJD Creutzfeldt-Jakob disease, CSF cerebrospinal fluid, DLB dementia with Lewy bodies, FTLD frontotemporal lobar degeneration, p-tau
181
tau protein phosphorylated at threonine 181, p-tau
rel
non-phosphorylated tau fraction, t-tau total tau protein