Fig. 5

Tg4510 mice presented short memory deficits during the novel object recognition test that were not rescued by TOMA treatment. Percentage of exploration (calculated as the time spent with the novel object divided by the sum of times spent with novel and familiar, multiplied by 100) of the novel object presented in the last trial of the novel object recognition test in nontransgenic mice (nTtg, white bars), Tet-only mice (Tet, grey bars), and Tg4510 mice treated with IgG1 (Tg4510 IgG1, black bars) or TOMA (Tg4510 TOMA, striped bars) for 5 months. Tg4510 mice spent significantly less time exploring the novel object compared to nontransgenic littermates, regardless of the treatment. Data presented as mean ± SEM, n = 10/group. **p < 0.01. TOMA tau oligomer monoclonal antibody