Skip to main content
Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound

Fig. 8

Reversal of reference memory impairment at 9 months posttreatment with P021 in 3 × Tg-AD mice. A set of animals separate from those employed for immunohistochemical and biochemical studies (Figs. 2, 3, 4, 5, 6 and 7) were treated with P021 diet (Tg-AD-P021) or vehicle diet (Tg-AD vh) and tested for behavioral changes to study the effect of the treatment on reversal of cognitive impairment in 3 × Tg-AD mice by the Morris Water Maze task. a Latency to escape; b distance traveled; c percent of time in target quadrant in probe trial 1 (PT1); d in PT2; e number of platform crossings in PT1 and f and in PT2. Animals were trained for four trials/day for 4 days. PT1 was conducted at 24 h after the last training session; PT2 was conducted at 20 days from PT1. The 3 × Tg-AD-vh mice were impaired in the Morris Water Maze task and P021 was able to prevent this deficit. *p < 0.05, **p < 0.01, ***p < 0.001. Wild-type (WT), n = 20; 3 × Tg-AD-vh, n = 15; 3 × Tg-AD-P021, n = 14. Data are shown as mean ± SD. AL adjacent left, AR adjacent right; Oq opposite quadrant, Tq target quadrant

Back to article page