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Table 3 Regression coefficients in linear model with cerebrospinal fluid tau phosphorylated at threonine 181 and tau as dependent variables of interaction terms between biomarkers and different variables

From: One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Interaction term

CSF cystathionine

CSF SAH

CSF 5-MTHF

Plasma Hcy

CSF p-tau181

 Age

−0.0011

−0.0098

0.0036

0.0113

 Sexa

−0.0652

−0.4815b

0.3443

−0.6850b

APOE ε4 genotypec

0.2169

0.5126b

−0.5687b

1.1427d

 CDR categorye

0.1877

0.2122

−0.2434

0.2833

CSF tau

 Age

 

−0.0076

0.0099

 

 Sexa

 

−0.7407f

0.4541

 

APOE ε4 genotypec

 

0.4953

−0.6965

 

 CDR categorye

 

0.1352

−0.2681

 
  1. Abbreviations: APOE Apolipoprotein E, CDR Clinical Dementia Rating, CSF Cerebrospinal fluid, Hcy Homocysteine, 5-MTHF 5-Methyltetrahydrofolate, p-tau181 Tau phosphorylated at threonine 181, SAH S-adenosyl-L-homocysteine
  2. Every interaction was tested in separate models, with only one interaction per model. Values of the regression interaction terms are reported, and their difference from 0 was assessed with an F test in analysis of variance
  3. aFemales (versus reference males)
  4. b p ≤ 0.05
  5. c APOE ε4 carriers (versus reference noncarriers)
  6. d p ≤ 0.001
  7. eCDR >0 (versus reference CDR 0)
  8. f p ≤ 0.01