One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Table 2 Regression coefficients in linear model with cerebrospinal fluid tau phosphorylated at threonine 181 and tau as dependent variables

Regression term	CSF cystathionine	CSF SAH	CSF 5-MTHF	Plasma Hcy
CSF p-tau181
Intercept	1.0719^a	1.0503^a	2.1744^a	1.1802^a
Age	0.0063^b	0.0038	0.0045^c	0.0054^c
Sex^d	−0.0279	−0.0223	−0.0140	−0.0236
APOE ε4 genotype^e	0.0328	0.0195	0.0362	0.0314
CDR category^f	0.1173^b	0.1182^b	0.1110^b	0.1186^b
Biomarker	0.1120	0.3195^b	−0.4965^a	0.1670
CSF tau
Intercept		1.4134^a	2.8174^a
Age		0.0073^c	0.0080^c
Sex^d		−0.0215	−0.0108
APOE ε4 genotype^e		0.0692	0.0894
CDR category^f		0.1758^a	0.1665^b
Biomarker		0.3803^b	−0.6269^a

Abbreviations: Aβ β-Amyloid, APOE Apolipoprotein E, CDR Clinical Dementia Rating, CSF Cerebrospinal fluid, Hcy Homocysteine, 5-MTHF 5-Methyltetrahydrofolate, p-tau181 Tau phosphorylated at threonine 181, SAH S-adenosyl-L-homocysteine
Values of the regression terms are reported, and their differences from 0 were assessed with a t test
^a p ≤ 0.001
^b p ≤ 0.01
^c p ≤ 0.05
^dFemales (versus reference males)
^e APOE ε4 carriers (versus reference noncarriers)
^f CDR >0 (versus reference CDR 0)

ISSN: 1758-9193