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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

Fig. 4

Improvement of diagnostic performance by addition of QC activity to logistic regression for AD prediction. Upper left: tau levels (open circles) of control (0) and AD (1) groups and logistic regression curve (red) with tau as a single parameter. Upper middle: logistic regression curve (red) calculated with tau and QC as variables and levels of combined tau–QC parameter (open circles) for control (0) and AD (1) groups. Upper right: ROC curves for results of logistic regression with tau alone (blue) or a tau–QC combination (red), p value from DeLongs test. Lower left: ptau levels (open circles) of control (0) and AD (1) groups and logistic regression curve (red) with ptau as a single parameter. Lower middle: logistic regression curve (red) calculated with ptau and QC as variables and levels of combined ptau–QC parameter (open circles) for control (0) and AD (1) groups. Lower right: ROC curves for results of logistic regression with ptau alone (blue) or a ptau–QC combination (red), p value from DeLongs test. AD Alzheimer’s disease, QC glutaminyl cyclase, ROC receiver operating characteristic (Colour figure online)

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