Comparison of CSF markers and semi-quantitative amyloid PET in Alzheimer’s disease diagnosis and in cognitive impairment prognosis using the ADNI-2 database

Table 5 Results of the stepwise linear regression investigating the association of baseline demographics, cerebrospinal fluid markers and positron emission tomography data, with baseline status and cognitive scores in the cross-sectional cohort

Association with	Baseline status (CTL, SMC/MCI, AD)		Baseline MMSE		Baseline CDR		Baseline ADAS-cog
	r ²	p Value	r ²	p Value	r ²	p Value	r ²	p Value
Sex	0.04	<0.001	0.04	<10⁻⁴	0.04	<0.001	0.08	<10⁻⁸
Age		ns	0.03	0.003		ns	0.04	<0.001
ApoE4		ns		ns		ns		ns
Baseline CSF
Aβ_1–42		ns		ns		ns		ns
Tau	0.06	<10⁻⁵	0.10	<10⁻⁹	0.07	<10⁻⁷	0.12	<10⁻¹¹
p-Tau₁₈₁		ns		ns		ns		ns
p-Tau/Aβ		ns		ns		ns		ns
Baseline PET
SUVr (pons)	0.18	<10^−19(*)	0.14	<10⁻¹⁵	0.14	<10⁻¹⁵	0.18	<10⁻²⁴
SUVr (crb)	0.10	<10^−6(*)	0.02	0.03 ^(*)		ns	0.05	0.001 ^(*)
SUVr (comp)	0.17	<10⁻¹⁷	0.14	<10^−14(*)	0.14	<10^−14(*)	0.19	<10^−23(*)

Abbreviations: AD Alzheimer’s disease, ADAS-cog Alzheimer’s Disease Assessment Scale–Cognitive Subscale, ApoE Apolipoprotein E, CDR Clinical Dementia Rating, Comp Composite, Crb Cerebellar, CSF Cerebrospinal fluid, MCI Mild cognitive impairment, MMSE Mini Mental State Examination, Pons Pontine, SMC Significant memory complaint, SUVr Standardised uptake value ratio, ns Not significant
All p values are corrected for multiple comparisons
(*): Remained an independent determinant when evaluated jointly

ISSN: 1758-9193