Table 3 Results of ROC analyses for standardised uptake value ratio and cerebrospinal fluid markers
SUVr (pons) | SUVr (crb) | SUVr (comp) | Aβ1–42 | Tau | p-Tau181 | p-Tau/Aβ | |
|---|---|---|---|---|---|---|---|
Cross-sectional cohort | |||||||
Optimal cut-off | 0.91 | 1.22 | 0.91 | 157 | 69 | 32 | 0.18 |
AUC | 0.88 | 0.84 | 0.88 | 0.83 | 0.85 | 0.79 | 0.85 |
Acc | 85% | 81% | 85% | 80% | 75% | 70% | 77% |
Se | 85% | 83% | 87% | 87% | 90% | 85% | 93% |
Sp | 85% | 79% | 83% | 75% | 63% | 59% | 65% |
Longitudinal cohort | |||||||
Optimal cut-off | 0.91 | 1.24 | 0.89 | 171 | 88 | 45 | 0.27 |
AUC | 0.85 | 0.84 | 0.86 | 0.85 | 0.81 | 0.80 | 0.85 |
Acc | 82% | 82% | 84% | 79% | 79% | 75% | 82% |
Se | 83% | 84% | 88% | 90% | 68% | 71% | 83% |
Sp | 82% | 81% | 81% | 70% | 87% | 79% | 81% |
PPV | 43% | 44% | 42% | 35% | 44% | 43% | 44% |
NPV | 94% | 95% | 96% | 96% | 90% | 91% | 94% |
RR | 7.2 | 8.1 | 9.6 | 8.0 | 4.6 | 4.6 | 7.6 |