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Table 3 Detailed clinical features of patients with progressive supranuclear palsy

From: Multireceptor fingerprints in progressive supranuclear palsy

Patient

Age at onset (years)

Age at death (years)

NINDS-SPSP criteria during life

Frontal presentation

Family history

Relevant medication in the last 3 months of life

Brain weight (g)

Tau pathology area 24'

Tau pathology caudate

1a

71

73

Probable

Nonfrontal

Negative

Clonazepam, temazepam, piracetam

1398

Grade 3

Grade 2

2

66

76

Probable

Frontal

Negative

Oxybutynin, acetylcysteine, thiopental, pancuronium

1060

Grade 3

Grade 2

3

63

68

Probable

Nonfrontal

Positive

Temazepam, oxybutynin

1405

Grade 3

Grade 4

4

70

79

Possible

Frontal

Positive

Tolterodine

1069

Grade 2

Grade 2

5

51

60

Probable

Frontal

Negative

Temazepam

1256

Grade 3

Grade 4

6a

74

80

Possible

Nonfrontal

Negative

Thiopental, pancuronium

1100

Grade 2

Grade 1

7

66

75

Possible

Frontal

Negative

Levomeprazine

1253

Grade 3

Grade 1

8

54

64

Possible

Frontal

Positive

Amantadine

1290

Grade 3

Grade 1

9

79

85

Possible

Nonfrontal

Negative

Oxazepam, nitrazepam, acetylcysteine

1175

Grade 2

Grade 2

10

68

79

Probable

Nonfrontal

Negative

Amitriptyline

922

Grade 2

Grade 1

11

60

72

Possible

Nonfrontal

Positive

Levodopa/carbidopa, amitriptyline

1045

Grade 2

Grade 2

12

60

67

Probable

Frontal

Positive

Levodopa/carbidopa, lormetazepam, nortriptyline

1013

Grade 4

Grade 2

13

62

70

Probable

Nonfrontal

Negative

Amantadine, temazepam, diazepam, amitriptyline

1160

Grade 2

Grade 3

14a

79

85

Possible

Nonfrontal

Negative

Alprazolam, tamsulosin, thiopental, pancuronium

1305

Grade 3

Grade 3

15

67

72

Possible

Nonfrontal

Positive

Levodopa/carbidopa

1525

Grade 2

Grade 4

16

61

69

Probable

Frontal

Positive

Midazolam, clozapine

1270

Grade 3

Grade 3

  1. NINDS-SPSP National Institute of Neurological Disorders and Stroke/Society for Progressive Supranuclear Palsy
  2. aPatients who underwent euthanasia by sodium thiopental and pancuronium bromide