Skip to main content

Table 2 Incident hypertension and incident hyperlipidemia in prediction of dementia

From: Increased dementia risk predominantly in diabetes mellitus rather than in hypertension or hyperlipidemia: a population-based cohort study

  

Event

PYs

Crude model

Adjusted modelb

  

HR

95% CI

p valuea

HR

95% CI

p valuea

DM cohort

 

333

89,101

1.54

1.36–1.74

<0.001

1.47

1.30–1.67

<0.001

 

Both HTN and HPL

126

24,637

1.10

0.81–1.51

0.539

0.90

0.66–1.24

0.529

 

HTN only

124

11,533

2.35

1.72–3.22

<0.001

1.17

0.85–1.60

0.341

 

HPL only

25

13,785

0.40

0.25–0.64

<0.001

0.72

0.45–1.17

0.189

 

No HTN and HPL

58

12,932

1.00

  

1.00

  

Non-DM cohort

 

981

395,250

1.00

  

1.00

  
 

Both HTN and HPL

130

24,367

2.79

2.28–3.41

<0.001

1.33

1.09–1.63

0.006

 

HTN only

418

59,711

3.70

3.21–4.25

<0.001

1.22

1.05–1.40

0.008

 

HPL only

31

12,468

1.31

0.90–1.89

0.154

1.28

0.89–1.85

0.187

 

No HTN and HPL

402

217,378

1.00

  

1.00

  
  1. CI confidence interval, COPD chronic obstructive pulmonary disease, DM diabetes mellitus, HTN hypertension, HPL hyperlipidemia, HR hazard ratio, PYs person-years
  2. aTested using Cox proportional hazards regression
  3. bAdjusted for age, sex, coronary heart disease, stroke, kidney disease, atrial fibrillation, depression, anxiety, heart failure, alcoholism, chronic obstructive pulmonary disease, obesity, and insurance amount