Fig. 1From: Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performanceSignificant premorbid personality and biomarker interaction effect on cognitive functioning. Dispersion diagram plot depicting the fit of a model with predicted cognitive performance score (ordinate axis) and an interaction between biomarker concentrations (abscissa axis) and premorbid personality. Lines, predicted centred values of premorbid personality traits. Left: with low neuroticism (N), greater ptau-181/Aβ1–42 concentrations predict lower CDR SoB scores, and thus better cognitive functioning. With relatively small ptau-181/Aβ1–42 value, the interaction effect is inversed. Middle: interaction between high agreeableness (A) level and high ptau-181/Aβ1–42 value predicts higher CDR SoB score, and thus lower cognitive functioning. Effect is inversed with relatively small ptau-181/Aβ1–42 concentrations. Right: at low conscientiousness (C) level, greater ptau-181/Aβ1–42 concentrations predict poorer cognitive performance (high CDR SoB score). With high C, smaller ptau-181/Aβ1–42 ratios predict better cognitive functioning (low CDR SoB score). CDR SoB Res residuals of clinical dementia rating Sum of Boxes score, Aβ amyloid beta, ptau phosphorylated tauBack to article page