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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Interaction between personality traits and cerebrospinal fluid biomarkers of Alzheimer’s disease pathology modulates cognitive performance

Fig. 1

Significant premorbid personality and biomarker interaction effect on cognitive functioning. Dispersion diagram plot depicting the fit of a model with predicted cognitive performance score (ordinate axis) and an interaction between biomarker concentrations (abscissa axis) and premorbid personality. Lines, predicted centred values of premorbid personality traits. Left: with low neuroticism (N), greater ptau-181/Aβ1–42 concentrations predict lower CDR SoB scores, and thus better cognitive functioning. With relatively small ptau-181/Aβ1–42 value, the interaction effect is inversed. Middle: interaction between high agreeableness (A) level and high ptau-181/Aβ1–42 value predicts higher CDR SoB score, and thus lower cognitive functioning. Effect is inversed with relatively small ptau-181/Aβ1–42 concentrations. Right: at low conscientiousness (C) level, greater ptau-181/Aβ1–42 concentrations predict poorer cognitive performance (high CDR SoB score). With high C, smaller ptau-181/Aβ1–42 ratios predict better cognitive functioning (low CDR SoB score). CDR SoB Res residuals of clinical dementia rating Sum of Boxes score, amyloid beta, ptau phosphorylated tau

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