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Table 2 Correlations between the products of APP processing in FAD mutation carriers

From: The effects of different familial Alzheimer’s disease mutations on APP processing in vivo

 

CSF biomarker

sAPPα

sAPPβ

38

40

42

MC

sAPPα

 

0.87 (<0.01)

0.2 (0.4)

0.09 (0.7)

-0.2 (0.4)

sAPPβ

0.87 (<0.01)

 

0.2 (0.3)

0.1 (0.6)

-0.2 (0.5)

38

0.2 (0.4)

0.2 (0.3)

 

0.93 (<0.0001)

0.44 (0.06)

40

0.09 (0.7)

0.1 (0.6)

0.93 (<0.0001)

 

0.6 (0.01)

42

-0.2 (0.4)

-0.2 (0.5)

0.44 (0.06)

0.6 (0.01)

 

APPswe

sAPPα

  

0.2 (0.6)

0.2 (0.7)

-0.03 (0.9)

sAPPβ

n.a.

n.a.

n.a.

n.a.

n.a.

38

0.2 (0.6)

  

0.9 (<0.001)

0.7 (0.06)

40

0.2 (0.7)

 

0.9 (<0.001)

 

0.8 (0.01)

42

-0.03 (0.9)

 

0.7 (0.06)

0.8 (0.01)

 

PSEN1

sAPPα

 

0.66 (0.18)

0.20 (0.7)

0.20 (0.7)

0.086 (0.9)

sAPPβ

0.66 (0.18)

 

0.60 (0.2)

0.60 (0.2)

0.54 (0.3)

38

0.20 (0.7)

0.60 (0.2)

 

1 (<0.01)

0.83 (0.06)

40

0.20 (0.7)

0.60 (0.2)

1 (<0.01)

 

0.83 (0.06)

42

0.086 (0.9)

0.54 (0.3)

0.83 (0.06)

0.83 (0.06)

 

NC

sAPPα

 

0.64 (<0.01)

0.71 (<0.01)

0.72 (<0.01)

0.65 (<0.01)

sAPPβ

0.64 (<0.01)

 

0.28 (0.3)

0.33 (0.2)

0.29 (0.3)

38

0.71 (<0.01)

0.28 (0.3)

 

0.98 (<0.0001)

0.95 (<0.0001)

40

0.72 (<0.01)

0.33 (0.2)

0.98 (<0.0001)

 

0.98 (<0.0001)

42

0.65 (<0.01)

0.29 (0.3)

0.95 (<0.0001)

0.98 (<0.0001)

 
  1. Correlations between the products of APP processing in the mutation carrier group as a whole (MC), carriers of the APPswe and PSEN1 mutations separately and in the nonmutation carriers (NC)
  2. Numbers represent Pearson/Spearman correlation coefficients (p values) (significant correlations in italics)
  3. APP amyloid precursor protein, FAD familial Alzheimer’s disease, amyloid beta, MC mutation carriers, NC noncarriers