Table 1 Subject characteristics

Age, years

66.8 (7.0)

64.4 (6.2)^b,c,d

68.2 (6.9)^a,c,d

67.3 (7.2)^a,b

66.9 (6.8)^a,b

Female sex, n (%)

1049 (43)

170 (38)^c

181 (37)^c

528 (51)^a,b,d

170 (34)^c

Years of education

11.1 (3.0)

11.9 (3.1)^b,c,d

11.4 (3.2)^a,c,d

10.8 (2.8)^a,b

10.5 (2.9)^a,b

MMSE score

23.6 (5.2)

28.3 (1.7)^b,c,d

26.5 (2.5)^a,c,d

20.4 (5.0)^a,b,d

23.0 (5.2)^a,b,c,

APOE ε4 allele carriers, n (%)

1186 (54)

158 (35)^b,c

242 (49)^a,c,d

615 (60)^a,b,d

171 (35)^b,c

CSF Aβ_1–42, pg/ml

667 (289)

906 (277)^b,c,d

676 (295)^a,c,d

504 (174)^a,b,d

781 (278)^a,b,c

CSF tau, pg/ml

527 (401)

317 (205)^b,c,d

486 (313)^a,c,d

705 (406)^a,b,d

394 (443)^a,b,c

CSF p-tau, pg/ml

70 (37)

52 (25)^b,c

70 (35)^a,c,d

88 (39)^a,b,d

50 (25)^b,c

Outcome at follow-up AD-type/no AD-type dementia (% AD-type dementia)

–

13/235 (5)

146/224 (61)

–

–

Average follow-up duration, years

–

2.93 (1.99)

2.41 (1.46)

–

–