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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

Fig. 2

FRM-36143 is a potent GSM in vitro. a FRM-36143 potency on Aβ42 in H4 cells (35 nM) compared to mouse primary cortical neurons (53 nM). Data represent mean ± SEM of 2–5 experiments run in duplicate. b Potency of FRM-36143 (>10 μM) compared to the potent GSI, LY-411,575 (0.8 nM) on Notch processing. Data represent mean ± SEM of 2–5 experiments run in duplicate or triplicate. c Peptide profile from the media of H4 cells treated with FRM-36143 measured by ELISA. EC50 values: Aβ37 = 186 nM, Aβ38 = 38 nM, Aβ40 = 167 nM, Aβ42 = 35 nM

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Alzheimer's Research & Therapy

ISSN: 1758-9193