Fig. 1

Baseline CSF DHA levels by APOE status. The distributions of baseline plasma phospholipid and CSF DHA, as well as the ratio of CSF to plasma DHA, are demonstrated by APOE genotype (n = 70). There were no significant differences in (a) plasma phospholipid or (b) CSF DHA levels by APOE genotype. c The ratio of CSF to plasma DHA by APOE genotype at baseline significantly differed between the APOE genotype groups (p = 0.03 for group comparison). d CSF Aβ42 levels were significantly lower in ɛ4 carriers at baseline (p = 0.01 for group comparison). DHA levels are reported as a percentage by weight. The groups were compared using linear regression with DHA level or CSF-to-plasma DHA ratio as the dependent variable and groups as the covariate.*p < 0.05 for group comparison. Aβ42 amyloid-β42, APOE apolipoprotein E, CSF cerebrospinal fluid, DHA docosahexaenoic acid, PL Phospholipids