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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: A single dose of the γ-secretase inhibitor semagacestat alters the cerebrospinal fluid peptidome in humans

Fig. 2

β-amyloid 22-28. The peptide EDVGSNK, constituting fragment 22-28 of β-amyloid within APP. a annotated MS2 spectrum. b Relative abundance of the peptide after semagacestat treatment. In the 280 mg dosage group the concentration of the peptide decreased to a minimum of 42 % at 9 h (p = 0.0035), while in the 140 mg dosage group the minimum relative abundance was 13 % at 12 h (p = 0.36). Graphed data are medians with median absolute deviations. APP amyloid precursor protein

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Alzheimer's Research & Therapy

ISSN: 1758-9193