Variable | 2 months (n = 273) | 6 months (n = 250) | 12 months (n = 214) | 18 months (n = 169) | 24 months (n = 140) | 30 months (n = 96) | 36 months (n = 78) |
---|---|---|---|---|---|---|---|
Completion rate (%) | 95.1 | 87.1 | 74.6 | 58.9 | 48.8 | 33.4 | 27.2 |
MMSE scorea | 18.2 (17.7, 18.6) | 17.4 (16.8, 18.0) | 15.8 (15.1, 16.4) | 14.7 (13.8, 15.5) | 13.9 (12.9, 14.9) | 13.7 (12.5, 14.9) | 12.8 (11.5, 14.1) |
ADAS-cog score (0–70)a | 28.8 (27.5, 30.2) | 32.3 (30.6, 34.0) | 35.0 (32.8, 37.1) | 35.9 (33.3, 38.5) | 36.4 (33.2, 39.5) | 39.4 (35.7, 43.1) | |
IADL scorea | 20.6 (20.0, 21.2) | 22.3 (21.6, 22.9) | 23.4 (22.6, 24.1) | 24.3 (23.6, 25.0) | 25.1 (24.3, 25.8) | 26.2 (25.5, 27.0) | |
PSMS scorea | 9.1 (8.6, 9.5) | 9.8 (9.3, 10.3) | 10.5 (9.9, 11.2) | 10.8 (10.2, 11.4) | 11.6 (10.8, 12.4) | 12.6 (11.6, 13.6) | |
MMSE score, change from baselinea | 1.77 (1.40, 2.14) | 1.01 (0.52, 1.50) | −0.60 (−1.18, −0.02) | −1.79 (−2.58, −1.01) | −2.82 (−3.73, −1.92) | −3.20 (−4.29, −2.11) | −4.03 (−5.22, −2.83) |
ADAS-cog score (0–70), change from baselinea | −0.14 (−1.19, 0.90) | −3.85 (−5.13, −2.57) | −6.56 (−8.26, −4.86) | −8.18 (−10.14, −6.23) | −9.52 (−11.98, −7.06) | −13.22 (−16.16, −10.28) | |
IADL score, change from baselinea | −1.48 (−1.89, −1.07) | −3.17 (−3.66, −2.67) | −4.09 (−4.73, −3.46) | −5.31 (−6.09, −4.52) | −6.19 (−7.23, −5.15) | −7.50 (−8.71, −6.30) | |
PSMS score, change from baselinea | −0.81 (−1.11, −0.51) | −1.74 (−2.13, −1.36) | −2.48 (−3.02, −1.94) | −2.99 (−3.53, −2.45) | −3.79 (−4.55, −3.04) | −4.85 (−5.83, −3.88) | |
MMSE score, improved/unchanged patients (%) | 74.5 | 66.4 | 51.5 | 45.2 | 32.8 | 36.7 | 28.9 |
ADAS-cog score (0–70), improved/unchanged patients (%) | 53.4 | 37.6 | 29.9 | 23.6 | 16.9 | 10.9 | |
IADL score, improved/unchanged patients (%) | 46.0 | 23.3 | 17.2 | 14.7 | 9.2 | 8.1 | |
PSMS score, improved/unchanged patients (%) | 62.4 | 45.5 | 34.9 | 23.3 | 21.8 | 17.6 |